Nature Search

Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3

Zheng Zhou
Hanqiao Feng
Yawen Bai
Research16 Mar 2011
Nature

Volume: 472, P: 234-237
Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques

Topical microbicide combined with vaccine effectively prevents infection of female macaques with simian immunodeficiency virus.

Mohammad Arif Rahman
Massimiliano Bissa
Genoveffa Franchini
ResearchOpen Access06 Apr 2023
Nature Microbiology

Volume: 8, P: 905-918
Publisher Correction: Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques

Mohammad Arif Rahman
Massimiliano Bissa
Genoveffa Franchini
Amendments and CorrectionsOpen Access22 May 2023
Nature Microbiology

Volume: 8, P: 1600
Conserved protein Pir2^ARS2 mediates gene repression through cryptic introns in lncRNAs

In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2^ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.

Gobi Thillainadesan
Hua Xiao
Shiv I. S. Grewal
ResearchOpen Access15 May 2020
Nature Communications

Volume: 11, P: 1-11
Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Patients with hemophilia lacking functional coagulation factor VIII (FVIII) are treated with replacement FVIII proteins. The development of neutralizing antibodies to the replacement FVIII, a major clinical problem, depends on the nature of the mutation in the gene encoding FVIII. The authors find that a prevalent inversion allele can unexpectedly produce FVIII protein, explaining why individuals with this allele do not frequently develop neutralizing antibodies.

Gouri Shankar Pandey
Chen Yanover
Elaine Reed
Research15 Sept 2013
Nature Medicine

Volume: 19, P: 1318-1324
Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence

p53-mediated replicative senescence is associated with downregulation of the inhibitory p53 isoform Δ133p42α. Horikawa et al.show that this downregulation is a result of specific targeting of Δ133p42α for autophagic degradation by the E3 ubiquitin ligase STUB1.

Izumi Horikawa
Kaori Fujita
Curtis C. Harris
Research21 Aug 2014
Nature Communications

Volume: 5, P: 1-11
Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer

The antiviral S-acyl-2-mercaptobenzamide thioester ejects an essential coordinated zinc ion from and induces aggregation and dysfunction of the HIV-1 nucleocapsid protein NCp7 via repetitive intracellular enzymatic acyl transfers, dependent on acetyl-CoA.

Lisa M Miller Jenkins
David E Ott
Ettore Appella
Research17 Oct 2010
Nature Chemical Biology

Volume: 6, P: 887-889
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

Uncapped telomeres activate a p53-mediated DNA damage response to elicit cellular senescence. In turn, p53 negatively modulates telomere capping by promoting ubiquitin-mediated degradation of the TRF2 shelterin component.

Kaori Fujita
Izumi Horikawa
Curtis C. Harris
Research07 Nov 2010
Nature Cell Biology

Volume: 12, P: 1205-1212

Search

Filter By:

Search

Quick links