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Showing 1–6 of 6 results
Advanced filters: Author: Lisa-Maria Needham Clear advanced filters

  • Single molecule tracking of fluorescent proteins in live cells is temporally limited by fluorophore photobleaching. Here the authors show using fluorophore pairs that FRET competes with photobleaching to improve photostability and allow longer-term tracking of both single proteins and complexes.

    • Srinjan Basu
    • Lisa-Maria Needham
    • Ernest D. Laue
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Combining localization and polarization microscopy can yield detailed insights into subcellular structures. POLCAM uses a polarization camera and wide-field microscopy for rapid measurement of super-resolution orientation imaging in live cells.

    • Ezra Bruggeman
    • Oumeng Zhang
    • Steven F. Lee
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 1873-1883

  • Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.

    • Lisa-Maria Needham
    • Carlos Saavedra
    • Randall H. Goldsmith
    Research
    Nature
    Volume: 629, P: 1062-1068

  • Visualization of endogenous G-quadruplexes (G4s) in living cells by fluorescence microscopy has been hampered by the high concentrations of G4-binding probes required, which can artificially induce additional G4 formation. Now, a G4-specific fluorescent probe (SiR-PyPDS) has been developed that enables single-molecule and real-time detection of individual G4 structures in living cells without perturbing G4 formation and dynamics.

    • Marco Di Antonio
    • Aleks Ponjavic
    • Shankar Balasubramanian
    Research
    Nature Chemistry
    Volume: 12, P: 832-837