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Showing 1–2 of 2 results
Advanced filters: Author: Lisanne Lutter Clear advanced filters

  • T regulatory (Treg) cells can differentiate into effector Treg (eTreg) cells that might be functional in inflammatory diseases. Using RNA sequencing and epigenetic profiling, the authors show that eTreg signatures in juvenile idiopathic arthritis joints are similar to tumour microenvironment (TME) Treg cells and are affected by tissue-specific epigenetic regulation.

    • Gerdien Mijnheer
    • Lisanne Lutter
    • Femke van Wijk
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Intraepithelial T cells (IETs) are a unique collection of T cells located at the epithelial barrier. This Review highlights the role of these cells in gut homeostasis and disease, including coeliac disease and IBD. Targeting of IETs in therapeutic interventions is also discussed.

    • Lisanne Lutter
    • David P. Hoytema van Konijnenburg
    • Femke van Wijk
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 15, P: 637-649