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Showing 1–5 of 5 results
Advanced filters: Author: Lise Queiroz Clear advanced filters

  • Autoimmune encephalitis (AIE) may involve neuron-specific cytotoxic T cells, but evidence is still lacking. Here the authors use induced pluripotent stem cells from patients with AIE and single cell RNA-sequencing of ex vivo CD8 T cells to find neuron-specific, KIR+CD8+ T cells with altered transcriptome that potentially contribute to AIE etiology.

    • Sylvain Perriot
    • Samuel Jones
    • Renaud Du Pasquier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Inventory data from more than 1 million trees across African, Amazonian and Southeast Asian tropical forests suggests that, despite their high diversity, just 1,053 species, representing a consistent ~2.2% of tropical tree species in each region, constitute half of Earth’s 800 billion tropical trees.

    • Declan L. M. Cooper
    • Simon L. Lewis
    • Stanford Zent
    ResearchOpen Access
    Nature
    Volume: 625, P: 728-734

  • Tumor neoantigens versus tumor-associated antigens may have different functions in antitumor immunity depending on the strength of antigen recognition. Here the authors characterize CD8 T cell clones specific for TAA, neoantigens or viral antigens isolated from tumor and blood and show that neoantigen-specific clones have a higher structural avidity than TAA-specific ones and preferentially infiltrate tumors.

    • Julien Schmidt
    • Johanna Chiffelle
    • Alexandre Harari
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477