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Showing 1–6 of 6 results
Advanced filters: Author: Lise Torp Jensen Clear advanced filters

  • Natural Killer cells regulate foetal growth. Here the authors use a humanized transgenic mouse to demonstrate that specific HLA-C KIR2DL interactions promote changes in maternal and foetal cell transcriptomes, resulting in modifications to placental vasculature, intercellular communications and foetal growth restriction.

    • Gurman Kaur
    • Caroline B. M. Porter
    • Lars Fugger
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-25

  • HLA-C expression levels correlate with immune responses to pathogens and autoimmunity, and vary in an allele-specific manner across individuals. Here the authors identify factors that drive differential expression of HLA-C allomorphs at the cell surface, and influence the structure of the peptide-binding cleft and diversity of peptides bound by HLA-C molecules.

    • Gurman Kaur
    • Stephanie Gras
    • Lars Fugger
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • This Review explores the complex roles of immune cells in the onset and progression of multiple sclerosis, describing the influence of environmental and genetic factors on immune cell phenotype and function. The authors highlight that teasing out the precise roles of different immune cell subsets at different stages of the disease will be key to effective treatment strategies.

    • Kathrine E. Attfield
    • Lise Torp Jensen
    • Lars Fugger
    Reviews
    Nature Reviews Immunology
    Volume: 22, P: 734-750