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Li, Huo, Zhang, Liu and colleagues report that the transcripts of genes involved in haematopoietic stem cell function share a protective mechanism against RNA decay through a non-canonical function of NAT10, independent of its N⁴-acetylcytidine catalytic activity.

Tandem electrosynthesis is challenging because sequential reaction steps often require incompatible chemical environments. Here, the authors report the creation of pH gradient via microenvironment engineering, enabling levulinic acid to γ-valerolactone conversion in a single electrolyzer.

This research reveals that platelet infiltration initiated by the platelet HuR-PSPF regulatory process coordinates systemic aging. Targeting platelet HuR may be a promising strategy for anti-aging interventions

Supported catalysts typically show reduced performance following their immobilisation on solid supports. Here, the authors report a supported polymeric catalyst which shows high productivity and selectivity for the synthesis of polyols from CO₂ and epoxides.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

Neuraminidase activity of NEU1 regulates insulin resistance and glucose tolerance. Here the authors report that NEU1 also inhibits hepatic gluconeogenesis in a non-enzymatic manner by binding SAM68, thereby activating GCN5 transcription.

Acoustic sensing devices are important to realize human‒machine interfaces. Here, the authors report the fabrication of freestanding reduced graphene oxide membranes with a diameter-to-thickness ratio of ~10⁶, leading to a static pressure responsivity of ~ 500 μm/Pa and high-performance microphone applications.

Most atmospheric water harvesters suffer from slow sorption and intermittent solar-driven desorption. Here, the authors develop a hybrid wood composite with a phase change material that stores solar heat. It rapidly captures water across a wide humidity range and releases it continuously, even in darkness, achieving a daily yield of 0.96–1.72 L kg⁻¹.

Tang et al. demonstrate that disease progression in Duchenne muscular dystrophy is driven not only by dystrophin deficiency but also by ANXA11-mediated failure of regenerative myofiber maturation. Targeting ANXA11 improves muscle regeneration and function in mdx mice.

Authors propose a triple-synergy strategy for dielectric ceramics that integrates medium-entropy superparaelectric design, local structural distortion and plate-like BiTO phase construction, thereby achieving remarkable energy storage performance.

Dendritic cells (DC) present antigens leading to CD8⁺ T cell activation and can induce antitumor immunity. Here, the authors perform a CRISPR screen and identify ERα as a negative regulator of antigen cross-presentation, with ERα-deficient or ERα-degraded DC vaccines potentiating antitumor responses in vivo.

The CLAVATA3 (CLV3)-WUSCHEL (WUS) feedback loop functions in shoot apical meristem maintenance. Liu et al. (2026) discovered that kinase Casein Kinase II act as nuclear effectors of G protein, linking CLV3 perception to WUS transcription.

Overcoming parasitic reactions between the electrolyte and electrodes is essential for realizing energy-dense lithium metal batteries. Here, the authors develop an oxygen distal fluorinated diluent that promotes a diluent- and anion-rich solvation structure, forming a stable inorganic-rich interphase and stable cycling in pouch cells at 500 Wh kg^–1 level.

Ketogenic diet (KD) generates β-hydroxybutyrate metabolites and has been shown to have context-dependent immunomodulatory effects. However, the effects of KD on inflammatory bowel disease (IBD) are controversial. Here, the authors investigate the pathogenic effects of KD in a preclinical model of DSS-induced colitis and identify a β-HB-Thomasclavelia spiroformis-γδ17 T cell axis that exacerbates inflammation and mucosal damage.

The authors report superconducting diode effect (SDE) at zero magnetic field in flakes and micro bridges of kagome CsV₃Sb₅, consistent with spontaneous time-reversal symmetry (TRS) breaking. They also demonstrate magnetic-field training, implying that the charge-density-wave state itself breaks TRS.

Dead metal severely inhibited the development of alkali metal batteries. Here, authors reactivated dead Na by a reverse-pulse-interspersed charging strategy, which enhanced the rate and cycle capabilities of anode-free battery, and showed wide applicability to various alkali metal batteries.

The malto-oligosaccharides (MOS) serve as essential primers for starch synthesis in higher plants. Authors demonstrate that two enzymes, PHS1 and DPE1, form a binary complex and coordinately promote MOS synthesis as a key initial step in starch biosynthesis.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

Satellite data reveal global methane emissions rebounded in 2024 despite a slowdown in atmospheric growth. This study highlights how fluctuations in wetlands and atmospheric sinks can mask progress on global methane mitigation efforts

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Molecular characteristics of amniote lineages can inform evolutionary inference. Here, the authors present a single-cell RNA-sequencing atlas of the chicken, which is applied to compare immune cells of chicken, turtle, duck and human, determining similarities and distinctions across amniote immune system evolution.

The substrate surface engineering approach prevents the formation of twin structures, while the elimination of twins greatly enhances carrier mobility and suppresses bipolar conduction, leading to optimized power factor in twin-free Bi₂Te₃ films.

CRISPRa screening in primary human cells has remained a formidable technical challenge. Here, the authors developed dCas12f1-SAM and successfully implemented a gain-of-function screen in primary human T cells, identifying key regulators of T cell activation.

Mitochondrial cristae structure is essential for energy production and immune regulation, but therapeutic strategies targeting cristae remodeling are lacking. Here, the authors show that targeting triose phosphate isomerase 1 restores cristae architecture, rewires microglial metabolism, and protects against ischemic stroke.

The neuroanatomical basis of auricular vagus nerve stimulation-induced analgesia remains unclear. Here, the authors identify an auricle-to-brain axis from the auricular concha to the ventrolateral periaqueductal gray, which engages the descending antinociceptive pathway.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Integrating single-cell multi-omics data remains challenging. Here, the authors benchmark 23 integration methods including foundation models across diverse datasets, revealing task-specific trade-offs and proposing an adaptation strategy that enhances foundation model performance.

High-performance perovskite tandem solar cells are limited by uneven, disordered self-assembled monolayer (SAM) acting as hole-selective layers. Luo et al. design a SAM that yields uniform, stable interfaces, reducing non-radiative losses and boosting efficiency and durability

Portal fibrosis, a hallmark of progression in chronic liver diseases, typically develops following biliary injury. This study identifies Clec3b⁺ fibroblasts as key drivers of liver portal fibrosis and demonstrates that a KLF4/periostin signaling axis controls their activation, highlighting potential therapeutic targets for inhibiting fibrosis in biliary diseases.

Zhang et al. report a multifunctional molecule to control the growth of quasi-2D perovskite nanocrystals, reducing defects and ion migration. This enables pure-red LEDs with an efficiency of 30.2%, operational stability of 8426 min, and 12.25 cm² devices maintaining above 20% efficiencies.

Li extraction from seawater is promising but challenged by low concentration and high Mg/Li ratio. Here, the authors report an integrated electrochemical system coupling Li extraction with in situ energy storage and H₂ production, upgrading seawater to a Li-rich solution with low energy consumption.

STX17 is critical for autophagosome–lysosome fusion. Here, the authors identified a new acetylation site of STX17 (K254) that plays an important role in STX17 translocation from the cytosolic pool onto autophagosomes, and this transport was driven by the motor protein myosin VI.

Gate residues, acting in concert with distal dynamic networks, are important yet underexploited regulators of enzymatic catalysis. Here, the authors report conformational dynamics analysis of fluoroacetate dehalogenase RPA1163, which reveals a gate-based allosteric pair (K181–W185) that governs substrate access and reactivity, and engineer this pair to obtain a highly active variant for turnover of α-fluorophenylpropionic acid.

Biomass electro-hydrogenation offers a sustainable route to value-added chemicals but suffers poor selectivity at high current densities. Here, the authors report an amide-functionalized Cu₃N catalyst enabling near-quantitative HMF-to-DHMF conversion under industrially relevant conditions.

The authors propose a 3D holographic method that generates physically consistent complex-valued light fields from multi-layer RGB-D data, achieving photorealistic defocus effects in scenes with transparency and reflection.

Cell fate decisions during early embryonic development require precise regulatory control. Here, the authors show that m6A RNA modification regulates primitive endoderm differentiation by modulating the stability of key transcripts during the second cell fate decision in mouse embryos.

The authors establish high-resolution spatiotemporal landscapes of AKI. They reveal that surviving epithelial cells are the primary drivers of kidney regeneration through proliferation, offering insights into the mechanism of kidney repair after AKI

Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

Most wood adhesives are formaldehyde-based, which is toxic, and requires energy intensive hot-pressing with long curing cycles. Here, the authors develop a cellulose-based homologous active adhesive which cures under ambient hydration, eliminating toxic emissions and reducing energy consumption.

Wang et al. report dual cationic imidazole ligands to control perovskite dimensionality, from 0D to parallel 1D, and bridged 1D structures. Bridged 1D/3D perovskite heterostructure enables solar cells with certified efficiency of 27.02% and 30×30 cm² solar modules with efficiency of 21.41%.

Triticum urartu is the diploid progenitor of polyploid wheat A subgenome. Here, the authors report an improved genome assembly of T. urartu and uncover a lipoxygenase gene that shapes T. urartu gene pools and their contributions to polyploid wheat A subgenome by regulating growth-defense trade offs.

Traditional single-cell models often overlook the proteomic context of cell phenotypes. Here, authors present CAPTAIN, a multimodal foundation model pretrained on 4.2 million cells. It aligns RNA and protein profiles to enhance cell annotation, protein imputation, and intercellular discovery.

Despite the success of CAR T cell-based immunotherapies, patients with non-Hodgkin lymphoma (NHL) face a high risk of recurrence. Here, the authors report clinical outcomes of a phaseI/II study on refractory NHL patients treated with anti-CD19-anti-CD20 CAR T cell product epigenetically reprogrammed with decitabine and CAR T cel properties. In addition, they investigate the persistence and fate of the CAR T cell product, indicating the acquisition of memory-like features, maintained cytotoxicity and reduced exhaustion signature.

This work introduces Siamese foundation models tailored for crystal structure prediction. The proposed approach achieves superior performance on downstream benchmarks and in superconductor validation tasks.

Here, the authors develop an autophagy-targeting influenza A virus attenuated vaccine that leverages the host autophagy machinery to manipulate viral protein degradation. This attenuated virus vaccine is able to elicit robust humoral, mucosal and cellular immune responses.

The authors report an artificial plateau neuron with bistable, spike-malleable dynamics that generates programmable rhythmic bursts, enabling a quadruped robot to walk adaptively and energy-efficiently via distributed hardware control without centralized computation.

By quantifying surface work functions and dielectric constants of phosphors via first-principles calculations, this work provides a general strategy for predicting and achieving self-recoverable mechanoluminescence based on contact electrification.

The authors introduce controlled compositional heterogeneity to broaden polarization vector distributions while preserving the antiferroelectric modulation in PbZrO₃-based ceramics. They reduce polarization hysteresis while maintaining high polarization strength.

AgBiS₂ nanocrystals show promise for thin, low-cost solar cells but are hindered by poor charge transport and limited infrared absorption. Yang et al. grow a molecular lead halide perovskite layer on the nanocrystals to passivate defects, improve transport, and enable highpower conversion efficiency.