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Showing 1–2 of 2 results
Advanced filters: Author: Liudmila Lapatsina Clear advanced filters

  • The stomatin domain protein STOML3 is required for the sensation of touch. Here, Poole et al.show that STOML3 enhances the activity of mechanosensitive Piezo1 and Piezo2 ion channels by reducing their activation thresholds, and that it achieves this through its stomatin domain.

    • Kate Poole
    • Regina Herget
    • Gary R. Lewin
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-14

  • The authors developed small-molecule inhibitors of STOML3 oligomerization, a membrane protein that interacts with mechanosensitive ion channels, such as Piezo2. One of these molecules was effective in silencing touch receptors and reversed touch-evoked pain associated with nerve injury or diabetic neuropathy.

    • Christiane Wetzel
    • Simone Pifferi
    • Gary R Lewin
    Research
    Nature Neuroscience
    Volume: 20, P: 209-218