Nature Search

Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control

The gut-microbiota-derived aromatic amino acid metabolite 4-hydroxyphenylacetic acid (4HPAA) and its analogues have been shown to protect against obesity. In mice, 4HPAA exerts anti-obesogenic effects by modulating mucosal immunity and lipid uptake in the intestine.

Zengliang Jiang
Liuqing He
Liang Tao
ResearchOpen Access14 Mar 2025
Nature Metabolism

Volume: 7, P: 808-822
Neoantigens combined with in situ cancer vaccination induce personalized immunity and reshape the tumor microenvironment

Mutation of cancer cells under the selective pressure of vaccines and the immunosuppressive tumor microenvironment limit therapeutic efficacy of cancer neoantigen vaccine. Here this group develops a nanovaccine delivering nAg and induce in situ cancer vaccination to synergistically promote a personalized immune response, enhance antigen diffusion, and improve the microenvironment by modulating immunosuppressive cells and activating the innate immune response.

Kuanhan Feng
Xinru Zhang
Ruoning Wang
ResearchOpen Access31 May 2025
Nature Communications

Volume: 16, P: 1-16
Longitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study

Here the authors measure viral load in samples from skin lesions, saliva, oropharynx, and rectum of 77 patients with acute monkeypox virus infection as well as from environmental fomite swabs and show a high seropositivity rate for antibodies against A29L and H3L.

Yang Yang
Shiyu Niu
Yingxia Liu
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-12
Engineering of a bona fide light-operated calcium channel

Existing optogenetic methods to induce calcium mobilisation lack selectivity and specificity. Here, the authors design and engineer a single-component light-operated calcium channel to provide optical control over calcium signals and calcium-dependent physiological responses: LOCa.

Lian He
Liuqing Wang
Yubin Zhou
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-11
A deep-learning-based framework for identifying and localizing multiple abnormalities and assessing cardiomegaly in chest X-ray

Accurate localization of abnormalities is crucial in the interpretation of chest X-rays. Here the authors present a deep learning framework for simultaneous localization of 14 thoracic abnormalities and calculation of cardiothoracic ratio, based on large X-ray dataset with bounding boxes created via a human-in-the-loop approach.

Weijie Fan
Yi Yang
Dong Zhang
ResearchOpen Access14 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Data-driven risk stratification and precision management of pulmonary nodules detected on chest computed tomography

Trained on a cohort of 45,064 cases and validated on data acquired from mobile computed tomography scanners deployed in rural China, a lung cancer screening deep learning model is shown to outperform existing lung cancer risk scores.

Chengdi Wang
Jun Shao
Weimin Li
ResearchOpen Access17 Sept 2024
Nature Medicine

Volume: 30, P: 3184-3195
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite

Carbohydrates are essential for regulating various biological processes. Here, the authors developed DeepGlycanSite, a deep learning model that accurately predicts carbohydrate-binding sites on proteins, offering insights into carbohydrate regulation of therapeutically important proteins.

Xinheng He
Lifen Zhao
Xi Cheng
ResearchOpen Access17 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Engineering of NEMO as calcium indicators with large dynamics and high sensitivity

The NEMO series of genetically encoded calcium indicators report calcium activity in neuronal and non-neuronal cells with high signal-to-baseline ratio, which is shown in neuronal culture, slice preparations, in vivo and in planta.

Jia Li
Ziwei Shang
Youjun Wang
ResearchOpen Access20 Apr 2023
Nature Methods

Volume: 20, P: 918-924
Evolutionary trajectory and characteristics of Mpox virus in 2023 based on a large-scale genomic surveillance in Shenzhen, China

Mpox virus has spread globally since 2022 with cases in many previously non-endemic countries including China. Here, the authors describe the genomic epidemiology of the first local outbreak in Shenzhen, China, including 92 cases reported from June–Oct 2023.

Shengjie Zhang
Fuxiang Wang
Yang Yang
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-11
Correction: 3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression

Jun Ni
Xiying Hou
Shougang Zhuang
Amendments and CorrectionsOpen Access18 Jul 2019
Cell Death & Disease

Volume: 10, P: 1
Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex

Hung and colleagues show that ALK-mediated CDK9 activation increases homologous recombination repair and PARP inhibition resistance and propose combinatorial inhibition of ALK and PARP as therapeutically beneficial for treatment-resistant tumors.

Yu-Yi Chu
Mei-Kuang Chen
Mien-Chie Hung
ResearchOpen Access17 Oct 2022
Nature Cancer

Volume: 3, P: 1211-1227
Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE

SspABCD–SspE is a phosphorothioation-sensing bacterial defence system. Here, authors find that SspE exploits DNA phosphorothioation-binding preference to modulate its biochemical activities for the self/nonself discrimination and phage resistance.

Haiyan Gao
Xinqi Gong
Lianrong Wang
ResearchOpen Access09 Nov 2022
Nature Communications

Volume: 13, P: 1-12
Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types

Genes normally expressed in the testis but aberrantly expressed in cancer are termed cancer testis antigens. In this study, the authors catalogue the expression of these genes in 19 different cancer types and correlate expression with some somatically mutated oncogenes.

Cheng Wang
Yayun Gu
Zhibin Hu
ResearchOpen Access27 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Integrated chemoenzymatic synthesis of a comprehensive sulfated ganglioside glycan library to decipher functional sulfoglycomics and sialoglycomics

Deciphering the sulfation and sialylation codes of ganglioside glycans is impeded by the limited accessibility of well-defined structures. Now, an integrated chemoenzymatic strategy has been developed for efficient synthesis of a comprehensive 65-membered ganglioside glycan library, enabling an extensive exploration into their structure–function relationships using glycan microarray technology.

Zhuojia Xu
Yating Liu
Tiehai Li
Research06 Jun 2024
Nature Chemistry

Volume: 16, P: 881-892
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

Composition of gut bacteria and serum metabolites in young, obese individuals is partially restored following weight loss surgery, including Bacteroides thetaiotaomicron, which decreases serum glutamate levels and fat mass gain in mice.

Ruixin Liu
Jie Hong
Weiqing Wang
Research19 Jun 2017
Nature Medicine

Volume: 23, P: 859-868
A prediction model for moderate to severe pain in primary hepatic carcinoma after chemotherapy: a multi-center prospective case‒control study

Siting Huang
Aiqin Liu
Xi Ke
ResearchOpen Access25 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy

Liuqing Yang
Ye Yang
Qiang Zhang
ResearchOpen Access18 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-13
Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy

The conventional view holds that hypoxia confers drug resistance. In contrast, here the authors use a multilayer ‘omics data approach to characterize the molecular features associated with tumour hypoxia and identify molecular alterations that correlate with both drug-resistant and drug-sensitive responses to approved drugs.

Youqiong Ye
Qingsong Hu
Leng Han
Research18 Mar 2019
Nature Metabolism

Volume: 1, P: 431-444
The LINK-A lncRNA interacts with PtdIns(3,4,5)P₃ to hyperactivate AKT and confer resistance to AKT inhibitors

Yang and colleagues report that the LINK-A lncRNA binds to the PIP₃ phospholipid, leading to enhanced AKT signalling, tumorigenesis and resistance to AKT inhibitors.

Aifu Lin
Qingsong Hu
Liuqing Yang
Research20 Feb 2017
Nature Cell Biology

Volume: 19, P: 238-251
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Yang and colleagues identify a lncRNA that controls HIF1α signalling to stabilize HIF1α under normoxic conditions, and promotes breast cancer tumorigenesis.

Aifu Lin
Chunlai Li
Liuqing Yang
Research11 Jan 2016
Nature Cell Biology

Volume: 18, P: 213-224
Significance of depth of invasion determined by MRI in cT1N0 tongue squamous cell carcinoma

Chunmiao Xu
Junhui Yuan
Hailiang Li
ResearchOpen Access13 Mar 2020
Scientific Reports

Volume: 10, P: 1-9
LncRNA SNHG16 induces proliferation and fibrogenesis via modulating miR-141-3p and CCND1 in diabetic nephropathy

Xiaohong Jiang
Qianying Ru
Shan Huang
Research05 Jun 2020
Gene Therapy

Volume: 27, P: 557-566
SWAV: a web-based visualization browser for sliding window analysis

Zhenglin Zhu
Yawang Wang
Ze Zhang
ResearchOpen Access10 Jan 2020
Scientific Reports

Volume: 10, P: 1-4
Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system

Ying Zhao
Yuke Zhong
Weitao Lu
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis

Li et al. show that ROR1–HER3 receptor tyrosine kinase signalling in breast cancer cells inhibits the MST1/2 Hippo pathway kinases through a lncRNA termed MAYA. The resulting activation of YAP promotes osteoclast differentiation for bone metastasis.

Chunlai Li
Shouyu Wang
Liuqing Yang
Research23 Jan 2017
Nature Cell Biology

Volume: 19, P: 106-119
Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress

A loss-of-function screen reveals a role for lncRNA DARS-AS1 in promoting cancer cell proliferation and further experiments shows DARS-AS1 regulates the PACT-PKR pathway, overall suggesting it as a potential target for cancer therapy and prognosis.

Liuqing Yang
Kequan Lin
Dong Wang
ResearchOpen Access15 Aug 2022
Communications Biology

Volume: 5, P: 1-13
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling

Yanyan Zhang
Baohua Li
Yuzhang Wu
ResearchOpen Access24 Mar 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-14
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits

Genome-wide analyses in 19,629 individuals identify 365 independent variants associated with brain volumetric phenotypes. The study provides insight into the overlapping genetic architecture of brain volume measures and cognitive and mental health traits.

Bingxin Zhao
Tianyou Luo
Hongtu Zhu
Research01 Nov 2019
Nature Genetics

Volume: 51, P: 1637-1644
A cross-sectional study of clinical characteristics and risk factors for hand eczema in the general Chinese population

Zilu Qu
Qian Jiang
Feng Hu
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Assessment of network module identification across complex diseases

In this DREAM challenge, 75 methods for the identification of disease-relevant modules from molecular networks are compared and validated with GWAS data. The authors provide practical guidelines for users and establish benchmarks for network analysis.

Sarvenaz Choobdar
Mehmet E. Ahsen
Daniel Marbach
ResearchOpen Access30 Aug 2019
Nature Methods

Volume: 16, P: 843-852
Overexpression of MdATG8i improves water use efficiency in transgenic apple by modulating photosynthesis, osmotic balance, and autophagic activity under moderate water deficit

Xin Jia
Ke Mao
Fengwang Ma
ResearchOpen Access01 Apr 2021
Horticulture Research

Volume: 8, P: 1-15
China Protocol for early screening, precise diagnosis, and individualized treatment of lung cancer

Chengdi Wang
Bojiang Chen
Weimin Li
ReviewsOpen Access27 May 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-7
Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1

Qi Yin
Hongye Wang
Jinsong Li
ResearchOpen Access18 Dec 2019
Cell Research

Volume: 30, P: 133-145
Genome wide identification of novel DNA methylation driven prognostic markers in colorectal cancer

Yuhua Ma
Yuanxin Li
Min Zhu
ResearchOpen Access08 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
Reflectance confocal microscopy for plaque psoriasis therapeutic follow-up during an anti-interleukin-17A monoclonal antibody: an observational study

Qian Jiang
Zilu Qu
Feng Hu
ResearchOpen Access02 Jul 2024
Scientific Reports

Volume: 14, P: 1-8
Overexpression of MdATG18a in apple improves resistance to Diplocarpon mali infection by enhancing antioxidant activity and salicylic acid levels

Xun Sun
Liuqing Huo
Fengwang Ma
ResearchOpen Access01 Nov 2018
Horticulture Research

Volume: 5, P: 1-10
Increasing the performance of Passion fruit (Passiflora edulis) seedlings by LED light regimes

Dangdi Liang
Ahmed Fathy Yousef
Faxing Chen
ResearchOpen Access25 Oct 2021
Scientific Reports

Volume: 11, P: 1-13
Correction to: Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect

Guili Hu
Yang Liu
Qingqing Wang
Amendments and Corrections18 Feb 2020
Cellular & Molecular Immunology

Volume: 17, P: 305-306
PD-1 blockade potentiates neoadjuvant chemotherapy in NSCLC via increasing CD127⁺ and KLRG1⁺ CD8 T cells

Zhenzhen Hui
Yulin Ren
Xiubao Ren
ResearchOpen Access25 May 2023
npj Precision Oncology

Volume: 7, P: 1-17
Plant phytochrome A in the Pr state assembles as an asymmetric dimer

Jiao Wang
Chen Zhou
Ping Yin
Correspondence04 Jul 2023
Cell Research

Volume: 33, P: 802-805
Bibliometric analysis and content analysis of digital entrepreneurship: utilizing the WoS and Scopus databases

Haijiao Liu
Jiahui Yu
Qing Liu
ReviewsOpen Access02 Apr 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-26
LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

Qingsong Hu
Chunlai Li
Liuqing Yang
Research10 Jan 2019
Cell Research

Volume: 29, P: 286-304
Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells

Yixuan Wang
Quan Chen
Xiaoying Wu
ResearchOpen Access12 Aug 2021
Cell Death & Disease

Volume: 12, P: 1-11
The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase α

Daiki Hayashi
Liuqing Wang
Yasuhito Shirai
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression

Jun Ni
Xiying Hou
Shougang Zhuang
ResearchOpen Access01 May 2019
Cell Death & Disease

Volume: 10, P: 1-15
MdATG18a overexpression improves basal thermotolerance in transgenic apple by decreasing damage to chloroplasts

Liuqing Huo
Xun Sun
Fengwang Ma
ResearchOpen Access01 Mar 2020
Horticulture Research

Volume: 7, P: 1-15
Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect

Guili Hu
Yang Liu
Qingqing Wang
Research26 Apr 2010
Cellular & Molecular Immunology

Volume: 7, P: 296-305
Chromosome-level genome assembly of the diploid oat species Avena longiglumis

Qing Liu
Gui Xiong
John Seymour Heslop-Harrison
ResearchOpen Access22 Apr 2024
Scientific Data

Volume: 11, P: 1-9

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