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Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma

During the progression of cutaneous squamous cell carcinoma (cSCC), dermal fibroblasts become activated into cancer-associated fibroblasts (CAFs) which are pro-tumorigenic. Here, using single-cell RNA sequencing of patients’ samples at different stages of cSCC progression, the authors identify two main CAF subsets and deduce their potential functions using bioinformatics.

Sabrina Schütz
Llorenç Solé-Boldo
Frank Lyko
ResearchOpen Access05 Sept 2023
Nature Communications

Volume: 14, P: 1-14
TET2 and TET3 loss disrupts small intestine differentiation and homeostasis

DNA demethylation is known to be critical for the development and function of many tissues. Here the authors show that it is also required for intestinal lineage differentiation, and that mice lacking DNA demethylases have altered microbiomes and a predisposition to inflammation.

Ihab Ansari
Llorenç Solé-Boldo
Yehudit Bergman
ResearchOpen Access06 Jul 2023
Nature Communications

Volume: 14, P: 1-18
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy

Understanding the immunological underpinnings of long-term survival in cancer is of high interest. Here, authors dissect the immune parameters of multiple myeloma long-term survivors following a single line of therapy longitudinally, and find sustained changes, including inflammation and impaired immune function.

Raphael Lutz
Florian Grünschläger
Simon Haas
ResearchOpen Access29 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

Solé-Boldo et al characterise dermal fibroblasts in human skin not exposed to sunlight by single-cell RNA sequencing. They identify fibroblast subpopulations and see that aging reduces their identity and predicted interactions with other skin cells, providing insights into age-related changes in skin.

Llorenç Solé-Boldo
Günter Raddatz
Frank Lyko
ResearchOpen Access23 Apr 2020
Communications Biology

Volume: 3, P: 1-12
Systematic perturbation of chromatin factors identifies regulatory networks during healthy and malignant hematopoiesis

In this issue of Nature Genetics, Lara-Astiaso et al. systematically characterized the functional roles of several chromatin factors in hematopoiesis by combining functional CRISPR screens with single-cell transcriptomics and chromatin accessibility profiling, revealing lineage biases and relationships with important transcription factors.

Llorenç Solé-Boldo
Simon Haas
News & Views01 Sept 2023
Nature Genetics

Volume: 55, P: 1430-1431
Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level

The spatial architecture of multiple myeloma remains to be explored. Here, the authors perform bulk and single cell sequencing for samples from newly diagnosed patients and reveal gene signatures associated with focal lesions and spatial heterogeneity in the tumour microenvironment.

Lukas John
Alexandra M. Poos
Niels Weinhold
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours

Avgustinova et al. report that targeting the H3K9 methyltransferase G9a in skin cancer does not affect single nucleotide variant profiles, but leads to increased tumour aggressiveness after a prolonged latency.

Alexandra Avgustinova
Aikaterini Symeonidi
Salvador Aznar Benitah
Research19 Nov 2018
Nature Cell Biology

Volume: 20, P: 1400-1409
Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

Ee Soo Lee
Llorenç Solé Boldo
Martin C. Harmsen
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-14

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