Nature Search

Insights from the Biorepository and Integrative Genomics pediatric resource

Genomic studies often lack representation from diverse populations, limiting equitable insights. Here, the authors show that the BIG Initiative captures extensive genetic diversity and reveals ancestry-linked health disparities in a community-based Mid-South cohort.

Silvia Buonaiuto
Franco Marsico
Vincenza Colonna
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-12
Correction: Corrigendum: IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

Chang-Min Lee
Chuan Hua He
Jack A. Elias
Amendments and CorrectionsOpen Access14 Nov 2016
Nature Communications

Volume: 7, P: 1
Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Angel G. Solis
Piotr Bielecki
Richard A. Flavell
Amendments and Corrections12 Nov 2019
Nature

Volume: 575, P: E7
Compartmentalized ocular lymphatic system mediates eye–brain immunity

A study provides evidence for a shared lymphatic circuit that connects the posterior eye and the brain, allowing the generation of immune responses to protect the CNS against pathogens and tumours following intravitreal immunization.

Xiangyun Yin
Sophia Zhang
Eric Song
ResearchOpen Access28 Feb 2024
Nature

Volume: 628, P: 204-211
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

SARS-CoV-2 infection can lead to progressive pathology in patients with COVID-19, but information for this disease progression is sparse. Here the authors use multi-omics approach to profile the immune responses of patients, assessing immune repertoire and effects of tocilizumab treatments, to find a dyssynchrony between innate and adaptive immunity in progressive COVID-19.

Avraham Unterman
Tomokazu S. Sumida
Charles S. Dela Cruz
ResearchOpen Access21 Jan 2022
Nature Communications

Volume: 13, P: 1-23
The kinetics of humoral response and its relationship with the disease severity in COVID-19

Lili Ren et al. investigate antibody response from 176 COVID-19 patients who presented different stages of their disease. This study suggests the late onset of antibody response as a risk factor for disease severity and a limited role of antibody titers in predicting the disease severity of COVID-19.

Lili Ren
Lulu Zhang
Jianwei Wang
ResearchOpen Access11 Dec 2020
Communications Biology

Volume: 3, P: 1-7
The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial

In a multicenter, randomized trial, the SGLT2 inhibitor dapagliflozin improved the health status and exercise function of patients with heart failure with preserved ejection fraction (HFpEF), a condition for which effective treatments are lacking.

Michael E. Nassif
Sheryl L. Windsor
Mikhail N. Kosiborod
ResearchOpen Access28 Oct 2021
Nature Medicine

Volume: 27, P: 1954-1960
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

PIEZO1 signalling mediates activation of a proinflammatory response to cyclical pressure fluctuations in immune cells.

Angel G. Solis
Piotr Bielecki
Richard A. Flavell
Research21 Aug 2019
Nature

Volume: 573, P: 69-74
IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

Chitinase 3-like 1 regulates cell death, inflammation and tissue remodelling via IL-13receptorα2. Here, the authors show that TMEM219 is a IL-13Rα2 co-receptor and modulates oxidant-induced apoptosis and lung injury, melanoma metastasis and TGF-β1 signalling, downstream of Chi3l1-IL-13Rα2.

Chang-Min Lee
Chuan Hua He
Jack A. Elias
ResearchOpen Access15 Sept 2016
Nature Communications

Volume: 7, P: 1-13
Implementation and performance analysis of QPSK system using pocket double gate asymmetric JLTFET for satellite communications

Lokesh Boggarapu
Lakshmi B
ResearchOpen Access21 Feb 2023
Scientific Reports

Volume: 13, P: 1-15
Delayed production of neutralizing antibodies correlates with fatal COVID-19

A longitudinal analysis of humoral immune responses in patients with COVID-19 with varying disease severities reveals that mortality does not correlate with antiviral antibody levels but, instead, with slower seroconversion.

Carolina Lucas
Jon Klein
Akiko Iwasaki
Research05 May 2021
Nature Medicine

Volume: 27, P: 1178-1186
Diverse functional autoantibodies in patients with COVID-19

Rapid extracellular antigen profiling of a cohort of 194 individuals infected with SARS-CoV-2 uncovers diverse autoantibody responses that affect COVID-19 disease severity, progression and clinical and immunological characteristics.

Eric Y. Wang
Tianyang Mao
Aaron M. Ring
Research19 May 2021
Nature

Volume: 595, P: 283-288
Longitudinal analyses reveal immunological misfiring in severe COVID-19

A longitudinal analysis of immune responses in patients with moderate or severe COVID-19 identifies a maladapted immune response profile linked to severe disease.

Carolina Lucas
Patrick Wong
Akiko Iwasaki
Research27 Jul 2020
Nature

Volume: 584, P: 463-469
Sex differences in immune responses that underlie COVID-19 disease outcomes

Male patients with COVID-19 have higher plasma levels of innate immune cytokines and chemokines such as IL-8, IL-18 and CCL5 and more non-classical monocytes than female patients, whereas female patients mount robust T cell activation maintained even in older age.

Takehiro Takahashi
Mallory K. Ellingson
Akiko Iwasaki
Research26 Aug 2020
Nature

Volume: 588, P: 315-320
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in COVID-19 patients with blood stream infections, matching reads of bacterial sequences from stool samples to organisms found in the blood.

Lucie Bernard-Raichon
Mericien Venzon
Jonas Schluter
ResearchOpen Access01 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Multiscale PHATE identifies multimodal signatures of COVID-19

Disease signatures in high-dimensional biomedical data are detected with a visualization algorithm.

Manik Kuchroo
Jessie Huang
Smita Krishnaswamy
Research28 Feb 2022
Nature Biotechnology

Volume: 40, P: 681-691
Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19

Carolina Lucas
Jon Klein
Akiko Iwasaki
Amendments and Corrections18 Jun 2021
Nature Medicine

Volume: 27, P: 1309
Validation of a novel NGS based BCR::ABL1 kinase domain mutation detection assay in Indian cohort

Pooja Chaudhary
Spandan Chaudhary
Neeraj Arora
ResearchOpen Access08 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients

Hyun Jung Kim
You-Sun Kim
Sei Won Lee
ResearchOpen Access14 Apr 2017
Experimental & Molecular Medicine

Volume: 49, P: e316
Unusual clinical manifestations and predominant stopgain ATM gene variants in a single centre cohort of ataxia telangiectasia from North India

Amit Rawat
Rahul Tyagi
Surjit Singh
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-12
Maximum depth sequencing reveals an ON/OFF replication slippage switch and apparent in vivo selection for bifidobacterial pilus expression

Christophe Penno
Mary O’Connell Motherway
Douwe van Sinderen
ResearchOpen Access10 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Screening of core filter layer for the development of respiratory mask to combat COVID-19

Lokesh K. Pandey
Virendra V. Singh
Kavita Agarwal
ResearchOpen Access13 May 2021
Scientific Reports

Volume: 11, P: 1-14
In-situ detoxification of schedule-I chemical warfare agents utilizing Zr(OH)₄@W-ACF functional material for the development of next generation NBC protective gears

Mohammad Imran
Virendra V. Singh
Kumaran Ganesan
ResearchOpen Access24 Dec 2021
Scientific Reports

Volume: 11, P: 1-21
Reliable and early diagnosis of bacterial blight in pomegranate caused by Xanthomonas axonopodis pv. punicae using sensitive PCR techniques

Pushpa Doddaraju
Pavan Kumar
Girigowda Manjunatha
ResearchOpen Access12 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Using a high throughput, random bacterial peptide display approach applied to patient serum samples, Haynes, Kamath, Bozekowski et al identify the antigens and epitopes that elicit a SARS-CoV-2 humoral response. They identify differences depending on disease severity and further in silico analysis suggests decreased epitope signal for Q677P but not for D614G mutant SARSCoV-2 strains.

Winston A. Haynes
Kathy Kamath
John C. Shon
ResearchOpen Access22 Nov 2021
Communications Biology

Volume: 4, P: 1-14
Advanced spectroscopic techniques for characterizing defects in perovskite solar cells

There is great interest in commercializing perovskite solar cells, however, the presence of defects and trap states hinder their performance. Here, recent developments in characterization techniques to investigate defects and ion migration in halide perovskites are reviewed.

Saurabh Srivastava
Sudhir Ranjan
Kanwar S. Nalwa
ReviewsOpen Access11 Jul 2023
Communications Materials

Volume: 4, P: 1-29

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Insights from the Biorepository and Integrative Genomics pediatric resource

Correction: Corrigendum: IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Compartmentalized ocular lymphatic system mediates eye–brain immunity

Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

The kinetics of humoral response and its relationship with the disease severity in COVID-19

The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

Implementation and performance analysis of QPSK system using pocket double gate asymmetric JLTFET for satellite communications

Delayed production of neutralizing antibodies correlates with fatal COVID-19

Diverse functional autoantibodies in patients with COVID-19

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Sex differences in immune responses that underlie COVID-19 disease outcomes

Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

Multiscale PHATE identifies multimodal signatures of COVID-19

Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19

Validation of a novel NGS based BCR::ABL1 kinase domain mutation detection assay in Indian cohort

The microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients

Unusual clinical manifestations and predominant stopgain ATM gene variants in a single centre cohort of ataxia telangiectasia from North India

Maximum depth sequencing reveals an ON/OFF replication slippage switch and apparent in vivo selection for bifidobacterial pilus expression

Screening of core filter layer for the development of respiratory mask to combat COVID-19

In-situ detoxification of schedule-I chemical warfare agents utilizing Zr(OH)₄@W-ACF functional material for the development of next generation NBC protective gears

Reliable and early diagnosis of bacterial blight in pomegranate caused by Xanthomonas axonopodis pv. punicae using sensitive PCR techniques

High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Advanced spectroscopic techniques for characterizing defects in perovskite solar cells

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