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Exploiting phage receptor binding proteins to enable endolysins to kill Gram-negative bacteria

Athina Zampara
Martine C. Holst Sørensen
Lone Brøndsted
ResearchOpen Access21 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Orally delivered toxin–binding protein protects against diarrhoea in a murine cholera model

Oral vaccines against Vibrio cholera have been critical for cholera management, but the production of more efficacious and cost-effective approaches is still needed. Here the authors deliver a bivalent V_HH construct that binds to cholera toxin and show protection in a murine cholera model.

Marcus Petersson
Franz G. Zingl
Sandra Wingaard Thrane
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice

Phage engineered with tail fibers and CRISPR–Cas reduce Escherichia coli load in animals.

Yilmaz Emre Gencay
Džiuginta Jasinskytė
Morten Otto Alexander Sommer
ResearchOpen Access04 May 2023
Nature Biotechnology

Volume: 42, P: 265-274
Comorbidities, multimorbidity and COVID-19

This Review discusses the effect of comorbidities and multimorbidity on the three mechanistically distinct phases of COVID-19, evaluating the evidence in the context of confounding factors and our evolving understanding of the disease.

Clark D. Russell
Nazir I. Lone
J. Kenneth Baillie
Reviews16 Feb 2023
Nature Medicine

Volume: 29, P: 334-343
Molecular engineering of safe and efficacious oral basal insulin

Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.

Frantisek Hubálek
Hanne H. F. Refsgaard
Thomas Kjeldsen
ResearchOpen Access27 Jul 2020
Nature Communications

Volume: 11, P: 1-9
Harnessing the microbiome to prevent global biodiversity loss

Careful and responsible microbiome management is a critical strategy to counter biodiversity loss, but practical and regulatory hurdles must be addressed to maximize its utility.

Raquel S. Peixoto
Christian R. Voolstra
Gabriele Berg
Reviews21 Jul 2022
Nature Microbiology

Volume: 7, P: 1726-1735
Author Correction: Molecular engineering of safe and efficacious oral basal insulin

Frantisek Hubálek
Hanne H. F. Refsgaard
Thomas Kjeldsen
Amendments and CorrectionsOpen Access20 Aug 2020
Nature Communications

Volume: 11, P: 1
GWAS, MWAS and mGWAS provide insights into precision agriculture based on genotype-dependent microbial effects in foxtail millet

Plant genotype alone appears to be insufficient to explain trait variations. This study integrates GWAS, MWAS and mGWAS in 827 foxtail millet cultivars, revealing that root-associated microbiota affect plant phenotypes in a host genotype-dependent manner.

Yayu Wang
Xiaolin Wang
Huan Liu
ResearchOpen Access07 Oct 2022
Nature Communications

Volume: 13, P: 1-17
Biogeography and environmental genomics of the Roseobacter-affiliated pelagic CHAB-I-5 lineage

Global sampling campaigns show that the CHAB-I-5 Roseobacter cluster is abundant in the marine environment, and found from the poles to the tropics. Analysis of the draft genome of strain SB2 reveals adaptation to an oligotrophic lifestyle.

Sara Billerbeck
Bernd Wemheuer
Meinhard Simon
Research16 May 2016
Nature Microbiology

Volume: 1, P: 1-8
Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis

Eva C Sonnenschein
Kristian F Nielsen
Lone Gram
Research23 Aug 2016
The ISME Journal

Volume: 11, P: 569-583
Who's who in biotech

Nature Biotechnology's readers select some of biotech's most remarkable and influential personalities from the past 10 years.

K S Jayaraman
Sabine Louët
Emily Waltz
Special Features02 Mar 2006
Nature Biotechnology

Volume: 24, P: 291-300
The ability of Phaeobacter inhibens to produce tropodithietic acid influences the community dynamics of a microalgal microbiome

Nathalie Nina Suhr Eiris Henriksen
Morten Dencker Schostag
Lone Gram
ResearchOpen Access03 Nov 2022
ISME Communications

Volume: 2, P: 1-11
Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov.

Sara Skøtt Paulsen
Thomas Isbrandt
Lone Gram
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
The potential to produce tropodithietic acid by Phaeobacter inhibens affects the assembly of microbial biofilm communities in natural seawater

Pernille Kjersgaard Bech
Sheng-Da Zhang
Lone Gram
ResearchOpen Access23 Mar 2023
npj Biofilms and Microbiomes

Volume: 9, P: 1-12
Protecting the piglet gut microbiota against ETEC-mediated post-weaning diarrhoea using specific binding proteins

Timothy Patrick Jenkins
Norbert Ács
Sandra Wingaard Thrane
ResearchOpen Access02 May 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-15
Erratum: Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis

Eva C Sonnenschein
Kristian F Nielsen
Lone Gram
Amendments and Corrections24 Jan 2017
The ISME Journal

Volume: 11, P: 588
Renewed insights into Ackermannviridae phage biology and applications

Anders Nørgaard Sørensen
Lone Brøndsted
ReviewsOpen Access21 Aug 2024
npj Viruses

Volume: 2, P: 1-11

Search

Exploiting phage receptor binding proteins to enable endolysins to kill Gram-negative bacteria

Orally delivered toxin–binding protein protects against diarrhoea in a murine cholera model

Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice

Comorbidities, multimorbidity and COVID-19

Molecular engineering of safe and efficacious oral basal insulin

Harnessing the microbiome to prevent global biodiversity loss

Author Correction: Molecular engineering of safe and efficacious oral basal insulin

GWAS, MWAS and mGWAS provide insights into precision agriculture based on genotype-dependent microbial effects in foxtail millet

Biogeography and environmental genomics of the Roseobacter-affiliated pelagic CHAB-I-5 lineage

Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis

Who's who in biotech

The ability of Phaeobacter inhibens to produce tropodithietic acid influences the community dynamics of a microalgal microbiome

Production of the antimicrobial compound tetrabromopyrrole and the Pseudomonas quinolone system precursor, 2-heptyl-4-quinolone, by a novel marine species Pseudoalteromonas galatheae sp. nov.

The potential to produce tropodithietic acid by Phaeobacter inhibens affects the assembly of microbial biofilm communities in natural seawater

Protecting the piglet gut microbiota against ETEC-mediated post-weaning diarrhoea using specific binding proteins

Erratum: Global occurrence and heterogeneity of the Roseobacter-clade species Ruegeria mobilis

Renewed insights into Ackermannviridae phage biology and applications

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