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Showing 1–6 of 6 results
Advanced filters: Author: Lora K. Picton Clear advanced filters

  • A design pipeline is presented whereby binding proteins can be designed de novo without the need for prior information on binding hotspots or fragments from structures of complexes with binding partners.

    • Longxing Cao
    • Brian Coventry
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 605, P: 551-560

  • H9T, an engineered IL-2 partial agonist, promotes the expansion of T cells while maintaining a stem-cell-like state, leading to improved efficacy of adoptive cell therapy in mouse models of melanoma and acute lymphoblastic leukaemia.

    • Fei Mo
    • Zhiya Yu
    • Warren J. Leonard
    Research
    Nature
    Volume: 597, P: 544-548

  • Synthetic chimeric orthogonal IL-2 receptors that incorporate the intracellular domain of receptors for other γ-chain cytokines such as IL-9 can reroute orthogonal signalling and alter the phenotype of T cells to improve anti-tumour responses.

    • Anusha Kalbasi
    • Mikko Siurala
    • K. Christopher Garcia
    ResearchOpen Access
    Nature
    Volume: 607, P: 360-365

  • A approach termed ‘receptor inhibition by phosphatase recruitment’ is described for attenuating both tonic and ligand-activated cell-surface receptor signalling.

    • Ricardo A. Fernandes
    • Leon Su
    • K. Christopher Garcia
    Research
    Nature
    Volume: 586, P: 779-784

  • Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient transcription factor reveals hundreds of alternative protein sequences that use diverse biochemical mechanisms to perform the derived function at least as well as the historical outcome.

    • Tyler N. Starr
    • Lora K. Picton
    • Joseph W. Thornton
    Research
    Nature
    Volume: 549, P: 409-413