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Showing 1–3 of 3 results
Advanced filters: Author: Lorene Brunello Clear advanced filters

  • Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but establish good ligandability of ATG8 isoforms through fragment screening and docking.

    • Martin P. Schwalm
    • Johannes Dopfer
    • Vladimir V. Rogov
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • In this work, the authors compile a chemogenomics library for NR1 nuclear hormone receptors to advance studies on unexplored therapeutic potential of these transcription factors. Its application in phenotypic settings revealed NR1 involvement in autophagy.

    • Laura Isigkeit
    • Espen Schallmayer
    • Daniel Merk
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13