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Showing 1–8 of 8 results
Advanced filters: Author: Lorna Rodriguez-Rodriguez Clear advanced filters

  • Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

    • Stig E Bojesen
    • Karen A Pooley
    • Alison M Dunning
    Research
    Nature Genetics
    Volume: 45, P: 371-384

  • Targeting solid tumours by chimeric antigen receptor (CAR) T cells require strategies that improve trafficking and effector function of these cells in the immunologically hostile cancer microenvironment. Here, authors show that CAR T cells engineered with incorporation of the CD28 transmembrane domain to the 4-1BB costimulatory domain and a membrane-bound form of IL-12 can achieve efficient anti-tumour activity and promote systemic disease targeting via regional T cell delivery in multi-metastatic disease models.

    • Eric Hee Jun Lee
    • John P. Murad
    • Saul J. Priceman
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Paul Pharoah, Joellen Schildkraut, Thomas Sellers and colleagues report a meta-analysis of genome-wide association studies for epithelial ovarian cancer and genotyping using the iCOGS array in 18,174 cases and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. They identify three new ovarian cancer susceptibility loci, including one specific to the serous subtype, and their integrated molecular analysis of genes and regulatory regions at these loci suggests disease mechanisms.

    • Paul D P Pharoah
    • Ya-Yu Tsai
    • Thomas A Sellers
    Research
    Nature Genetics
    Volume: 45, P: 362-370

  • HNF1B is overexpressed in the clear cell subtype and epigenetically silenced in the serous subtype of ovarian cancer. Pearce and colleagues now show that genetic variants in HNF1B are differentially associated with risks of developing these two cancer subtypes, possibly through an epigenetic mechanism.

    • Hui Shen
    • Brooke L. Fridley
    • Celeste Leigh Pearce
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-10

  • Fusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC patient carrying the NCOA4-RET fusion.

    • Bhavna S. Paratala
    • Jon H. Chung
    • Kim M. Hirshfield
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13