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Showing 1–5 of 5 results
Advanced filters: Author: Lotta Happonen Clear advanced filters

  • Characterizing host-pathogen protein interactions can help elucidate the molecular basis of bacterial infections. Here, the authors use an integrative proteomics approach to generate a quantitative map of protein interactions between Streptococcus pyogenes and human saliva and plasma.

    • Lotta Happonen
    • Simon Hauri
    • Johan Malmström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Group A Streptococcus exploits the human fibrinolytic system to promote infection. Here, the authors reveal that the bacterial toxin streptolysin O binds to plasminogen and accelerates its conversion to plasmin, thereby dismantling blood clots and facilitating the spread within the human host.

    • Di Tang
    • Hamed Khakzad
    • Johan Malmström
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Here, the authors elongated the hinge structure of IgG1 monoclonal antibodies. The modified IgG1-IgG3 hybrid subclass showed enhanced Fc-mediated function compared to IgG1 in two distinct biological systems, Streptococcus pyogenes and SARS-CoV-2.

    • Arman Izadi
    • Yasaman Karami
    • Pontus Nordenfelt
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-22

  • Tagging of the endogenous type II chaperonin TRiC complex using CRISPR knock-in enables its purification for cryo-EM. A series of structures reveal the fate of substrates and co-chaperones inside the TRiC chamber to uncover its inner workings.

    • John J. Kelly
    • Dale Tranter
    • Wyatt W. Yue
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 420-429

  • Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma and bacteria.

    • Simon Hauri
    • Hamed Khakzad
    • Lars Malmström
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10