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Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism

Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.

Yong Fan
Liwei Lyu
Oluf Pedersen
ResearchOpen Access31 Jul 2025
Nature Microbiology

Volume: 10, P: 1918-1939
Proteomic changes upon treatment with semaglutide in individuals with obesity

Using serum samples collected from participants of the STEP 1 and STEP 2 trials, the authors have uncovered changes to the proteome upon semaglutide treatment, which can shed light on the mechanism of action of the drug driving its benefits in obesity-related conditions.

Lasse Maretty
Dipender Gill
Milan Geybels
ResearchOpen Access03 Jan 2025
Nature Medicine

Volume: 31, P: 267-277
Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning

Osteoarthritis can be caused by multiple biological mechanisms but the drivers of disease risk are not well understood. Here, the authors use data from UK Biobank in machine learning models to identify clinical and biological markers associated with development of osteoarthritis and identify sub-groups with different risk profiles.

Rikke Linnemann Nielsen
Thomas Monfeuga
Ramneek Gupta
ResearchOpen Access01 Apr 2024
Nature Communications

Volume: 15, P: 1-17
Development of contractile properties in the fetal porcine urinary bladder

Lotte K Jakobsen
Karina F Trelborg
L H Olsen
Research04 Oct 2017
Pediatric Research

Volume: 83, P: 148-155

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Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism

Proteomic changes upon treatment with semaglutide in individuals with obesity

Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning

Development of contractile properties in the fetal porcine urinary bladder

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