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A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8⁺ T cell fitness in solid tumours

Through a functional CRISPR/Cas9 screening, Pretto et al. identify Elovl1 as a target to improve antitumour immunity by remodelling T cell lipid metabolism.

Samantha Pretto
Qian Yu
Massimiliano Mazzone
ResearchOpen Access10 Mar 2025
Nature Metabolism

Volume: 7, P: 508-530
Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

Two side-by-side papers report that H3K27me3 deposited by polycomb repressive complex 2 represents an epigenetic barrier that restricts naive human pluripotent cell differentiation into alternative lineages including trophoblasts.

Dick W. Zijlmans
Irene Talon
Vincent Pasque
ResearchOpen Access13 Jun 2022
Nature Cell Biology

Volume: 24, P: 858-871

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A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours

Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction

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A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8⁺ T cell fitness in solid tumours