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Showing 1–5 of 5 results
Advanced filters: Author: LouJin Song Clear advanced filters

  • Song and colleagues show that FDA-approved cough suppressant dextromethorphan could be used as an agonist of sigma non-opioid intracellular receptor 1 (SIGMAR1) to normalize the action potential in human cellular models and a mouse model of Timothy syndrome, a congenital disease with no available treatment. The researchers also show that dextromethorphan normalizes the action potential in human cellular models of two additional inherited cardiac arrhythmias: long QT syndrome types 1 and 2, which are caused by mutations in different genes.

    • LouJin Song
    • Ramsey Bekdash
    • Masayuki Yazawa
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 142-156

  • Branched chain ketoacid dehydrogenase kinase (BDK) inhibits the activity of branched chain ketoacid dehydrogenase and branched chain amino acid degradation, implicated in several diseases. Here, the authors discover a BDK inhibitor and degrader that shows efficacy in rodent metabolism and heart failure models, as well as another class of BDK inhibitors that stabilizes BDK.

    • Rachel J. Roth Flach
    • Eliza Bollinger
    • Kevin J. Filipski
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • A tissue culture system that provides an increasing intensity of electromechanical stimulation over time enables an in vitro model of cardiac tissue derived from human induced pluripotent stem cells to develop many of the characteristics of adult cardiac tissue.

    • Kacey Ronaldson-Bouchard
    • Stephen P. Ma
    • Gordana Vunjak-Novakovic
    Research
    Nature
    Volume: 556, P: 239-243

  • Cardiac tissues are derived from hiPS cells and electromechanically matured toward an adult-like phenotype. This protocol also describes optimized methods for analyses of function, ultrastructure, and cellular properties of these tissues.

    • Kacey Ronaldson-Bouchard
    • Keith Yeager
    • Gordana Vunjak-Novakovic
    Protocols
    Nature Protocols
    Volume: 14, P: 2781-2817