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Showing 1–7 of 7 results
Advanced filters: Author: Louis-Charles Campeau Clear advanced filters
  • Aryl thianthrenium salts participate in Suzuki–Miyaura cross-coupling reactions with boronic acids. Notably, the reactions occur at low pH, facilitating the use of base-sensitive boronic acids or Lewis basic substrates.

    • Louis-Charles Campeau
    News & Views
    Nature Synthesis
    Volume: 3, P: 1448-1450
  • The Grignard reaction represents one of the most powerful carbon-carbon bond forming reactions and is the subject of continual study. Here, the authors report a halide effect on the diastereoselectivity of 1,2-addition reactions to β-hydroxy ketones involving Grignard reagents, serving as a foundation for the rapid production of C4’-modified nucleosides with diversifiable positions at the nucleobase and C4’.

    • Garrett Muir
    • Guillermo Caballero-García
    • Robert Britton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Aziridines — three-membered nitrogen-containing heterocycles — are important synthetic targets, but N-alkyl aziridines are difficult to synthesize. Now, an electrochemical method, involving a dicationic intermediate, enables the coupling of alkenes and amines.

    • Tiffany Piou
    • Louis-Charles Campeau
    News & Views
    Nature Chemistry
    Volume: 13, P: 1027-1028
  • The gap between fundamental academic research and the applied industrial research that is necessary to ensure real-world applications can be bridged by engaging in well-defined collaborative academia–industry projects and fostering better communication between the scientists involved in them.

    • Danielle Schultz
    • Louis-Charles Campeau
    Comments & Opinion
    Nature Chemistry
    Volume: 12, P: 661-664
  • Leveraging enzymatic selectivity, a single reaction stream provides a single diastereomer of the cyclic dinucleotide MK-1454, a promising immune-oncology drug candidate, without the use of protecting groups or chiral auxiliaries.

    • John A. McIntosh
    • Zhijian Liu
    • Matthew L. Maddess
    Research
    Nature
    Volume: 603, P: 439-444
  • The development of nucleoside analogs for use as antiviral agents and antisense oligonucleotides requires efficient synthetic methods. This three-step approach starts with proline-catalyzed fluorination of simple heteroaryl-substituted aldehydes.

    • Emma K. Davison
    • David A. Petrone
    • Robert Britton
    Protocols
    Nature Protocols
    Volume: 17, P: 2008-2024
  • Glycomimetics are structural mimics of carbohydrates that can replicate their biological activity but have improved drug-like properties. Here, using proline-catalysed α-halogenation/aldol cascades, carbohydrate building blocks are readily assembled and then diversified into glycomimetics including imino- and carbasugars.

    • Michael Meanwell
    • Gaelen Fehr
    • Robert Britton
    ResearchOpen Access
    Communications Chemistry
    Volume: 4, P: 1-9