SAM-dependent methyltransferases (MTases) are crucial enzymes involved in various biological processes and are considered promising drug targets. Here, the authors synthesize SAM analogues with a squaramide moiety mimicking the methionine side chain, demonstrating potent and specific inhibitory effects on RNA MTase METTL3/14 activity.
- Jianxun Du
- Batoul Mahcene
- Bruno Sargueil
