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Showing 1–2 of 2 results
Advanced filters: Author: Luc Provencher Clear advanced filters

  • Discovering molecular pathways that sensitize cells to poly(ADP-ribose) polymerase (PARP)- trapping inhibitors is important for anti-cancer therapy. Here, the authors report that inactivation of the CHD6 chromatin remodelling enzyme sensitizes cells to PARP inhibitors via reduced abasic site repair, PARP-1 accumulation on chromatin, and replication stress.

    • Luc Provencher
    • Wilson Nartey
    • Aaron A. Goodarzi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24

  • Understanding how cancers react to poly(ADP-ribose) polymerase (PARP) trapping on DNA is crucial to thwart PARP inhibitor resistance. A recent study finds that trapped PARP1 is removed via the ubiquitin-dependent segregase p97, and that perturbing this molecular cascade increases PARP inhibitor cytotoxicity.

    • Peter M. Brownlee
    • Luc Provencher
    • Aaron A. Goodarzi
    News & Views
    Nature Cell Biology
    Volume: 24, P: 2-4