The activity of protein kinase A (PKA) is regulated by association and dissociation of its regulatory (R) subunits. The E3 ubiquitin ligase praja2 is now shown to ubiquitylate and stimulate the degradation of the R subunits in response to elevated cAMP levels.
- Luca Lignitto
- Annalisa Carlucci
- Antonio Feliciello
