Uromodulin is the most abundant urinary protein. Here, the authors discuss the physiological roles of uromodulin, the mechanisms by which mutations in theUMOD gene, which encodes uromodulin, cause autosomal dominant tubulointerstitial kidney disease and the association of common UMODvariants with complex disorders in the general population.
- Olivier Devuyst
- Eric Olinger
- Luca Rampoldi
