Optogenetic suppression of layer 4 in the sensory cortex reveals a surprising role for its activity in the cortical microcircuit: layer 4 suppresses the main cortical output layer—layer 5—through a direct translaminar inhibitory circuit. This translaminar inhibition sharpens spatial representations in the somatosensory cortex.
- Scott Pluta
- Alexander Naka
- Hillel Adesnik
