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Showing 1–3 of 3 results
Advanced filters: Author: Lucy V. Norling Clear advanced filters

  • Evidence indicates that resolution of acute inflammation is an active process, and resolvins — a family of lipid mediators enzymatically generated within resolution networks — possess unique and specific functions to orchestrate catabasis, the phase in which disease declines. Resolvin D2 is now shown to reduce excessive neutrophil trafficking to inflammatory sites and to decrease leukocyte interactions with endothelial cells in a nitric-oxide-dependent manner.

    • Matthew Spite
    • Lucy V. Norling
    • Charles N. Serhan
    Research
    Nature
    Volume: 461, P: 1287-1291

  • The authors discuss the preclinical evidence that provides insights into the mechanisms, pathways and mediators that set in motion resolution of inflammation. The time is ripe to establish if, and how, this biology can inform therapeutic innovation in the context of chronic inflammatory diseases.

    • Mauro Perretti
    • Dianne Cooper
    • Lucy V. Norling
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 87-99