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Showing 1–3 of 3 results
Advanced filters: Author: Lucyna Lubkowska Clear advanced filters

  • Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the head-on orientation, and an RNA–DNA hybrid can form in front of Pol II, creating a topological lock trapping Pol II at the fork.

    • Taryn M. Kay
    • James T. Inman
    • Michelle D. Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • What happens to histones during transcription is not well understood. Atomic force microscopy snapshots of RNA polymerase II (Pol II)-nucleosome complexes before, during and after transcription show the presence of looped transcriptional intermediates. In addition, a fraction of transcribed histones are remodeled to hexasomes, and the size of this fraction depends on the elongation rate of Pol II.

    • Lacramioara Bintu
    • Marta Kopaczynska
    • Carlos Bustamante
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1394-1399