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Showing 1–9 of 9 results
Advanced filters: Author: Ludovic Sauguet Clear advanced filters

  • Alcohols and anaesthetics exert their effects by potentiating ligand-gated ion channels. Here, the authors determine crystal structures of a bacterial ligand-gated ion channel in the presence of alcohols and anaesthetics, and describe a structural mechanism for stabilization of the open form of the channel.

    • Ludovic Sauguet
    • Rebecca J. Howard
    • Marc Delarue
    Research
    Nature Communications
    Volume: 4, P: 1-10

  • The single stranded DNA binding protein RPA plays a pivotal role in DNA replication. The archaeal RPA hosts a WH domain that interacts with the DNA primase and the replicative polymerase PolD. Here the authors provide a molecular understanding of the regulatory activity of archaeal RPA.

    • Markel Martínez-Carranza
    • Léa Vialle
    • Ludovic Sauguet
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Family D replicative DNA polymerases (PolD) contain a unique proofreading active site. Here, the authors present structures of PolD and enzymatic studies, revealing an unanticipated correction mechanism that extends the repertoire of protein domains known to be involved in DNA proofreading.

    • Leonardo Betancurt-Anzola
    • Markel Martínez-Carranza
    • Ludovic Sauguet
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Here the authors present the structure of Replication Protein A (RPA) in Archaea. The RPA structure from P. abyssi has been determined in presence and absence of DNA, providing insights into the evolution of this replication factor in eukaryotes

    • Clément Madru
    • Markel Martínez-Carranza
    • Ludovic Sauguet
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. Here, the authors present a cryo-EM structure of the DNA-bound PolD–PCNA complex from Pyrococcus abyssi to reveal the molecular basis for the interaction and cooperativity between a replicative DNAP and PCNA.

    • Clément Madru
    • Ghislaine Henneke
    • Ludovic Sauguet
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic signaling in response to neurotransmitter binding, but the conformational changes induced by neurotransmitter binding are unknown. The crystal structures of mutated GLIC, a bacterial pLGIC homolog, reveal a novel, locally closed channel conformation that provides insight into pLGIC allosteric transitions.

    • Marie S Prevost
    • Ludovic Sauguet
    • Pierre-Jean Corringer
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 642-649