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Showing 1–4 of 4 results

Advanced filters: Author: Ludvig Ekdahl Clear advanced filters

Essential genes shape cancer genomes through linear limitation of homozygous deletions

Maroulio Pertesi, Ludvig Ekdahl et al. identify genes that limit homozygous deletions in cancer cells. This study provides insight into how the location of essential genes affects deletion events, which can be used to identify potentially targetable vulnerabilities in cancer.

Maroulio Pertesi
Ludvig Ekdahl
Björn Nilsson
ResearchOpen Access19 Jul 2019
Communications Biology

Volume: 2, P: 1-11
Deciphering the genetics and mechanisms of predisposition to multiple myeloma

Multiple myeloma (MM) is an incurable blood malignancy. Here, the authors report 35 MM risk loci and two causal mechanisms for genetic MM risk: longer telomeres and elevated plasma B-cell maturation antigen (BCMA) and interleukin−5 receptor alpha (IL5RA) levels.

Molly Went
Laura Duran-Lozano
Björn Nilsson
ResearchOpen Access05 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing

Efficient deconvolution of antibody targets is needed for phenotype-based discovery. Here, the authors investigate a deconvolution approach based on pooled CRISPR Cas9 to achieve 97% deconvolution success rate.

Jenny Mattsson
Ludvig Ekdahl
Björn Nilsson
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-8
Genome-wide CRISPR/Cas9 screen identifies regulators of BCMA expression on multiple myeloma cells

Ram Ajore
Jenny Mattsson
Björn Nilsson
CorrespondenceOpen Access25 Jan 2024
Blood Cancer Journal

Volume: 14, P: 1-4