Nature Search

Two major ecological shifts shaped 60 million years of ungulate faunal evolution

Here, the authors analyze a fossil dataset spanning 60 million years to investigate ecological stability. Their network analysis identifies prolonged stability interrupted by two major functional transitions in ungulate assemblages linked to tectonic and climatic events.

Fernando Blanco
Ignacio A. Lazagabaster
Juan L. Cantalapiedra
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-11
A short linear peptide that folds into a native stable β-hairpin in aqueous solution

Francisco J. Blanco
Germán Rivas
Luis Serrano
Research01 Sept 1994
Nature Structural Biology

Volume: 1, P: 584-590
De novo design and structural analysis of a model β-hairpin peptide system

Marina Ramírez-Alvarado
Francisco J. Blanco
Luis Serrano
Research01 Jul 1996
Nature Structural Biology

Volume: 3, P: 604-612
The hydrophobic-staple motif and a role for loop-residues in α-helix stability and protein folding

Victor Muñoz
Francisco J. Blanco
Luis Serrano
Research01 May 1995
Nature Structural Biology

Volume: 2, P: 380-385
Membrane leakiness after viral infection and a new approach to the development of antiviral agents

Luis Carrasco
Research20 Apr 1978
Nature

Volume: 272, P: 694-699
A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin dynamics, neuronal function and memory formation in mice.

Patryk Poliński
Marta Miret Cuesta
Manuel Irimia
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-21
Timing and duration of calorie restriction determine its impact on ovarian aging in female mice

Juliane B. Prosczek
Jéssica D. Hense
Augusto Schneider
ResearchOpen Access09 Oct 2025
npj Aging

Volume: 11, P: 1-8
Elucidating the folding problem of helical peptides using empirical parameters

Victor Muñoz
Luis Serrano
Research01 Jun 1994
Nature Structural Biology

Volume: 1, P: 399-409
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Pharmacologic suppression of target cell recognition by engineered T cells expressing chimeric T-cell receptors

Luis Álvarez-Vallina
Rosa Yañez
Stephen J Russell
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 526-529
Loop length, intramolecular diffusion and protein folding

Ana-Rosa Viguera
Luis Serrano
Research01 Nov 1997
Nature Structural Biology

Volume: 4, P: 939-946
Different folding transition states may result in the same native structure

Ana Rosa Viguera
Luis Serrano
Matthias Wilmanns
Research01 Oct 1996
Nature Structural Biology

Volume: 3, P: 874-880
Implications of human–wildlife conflict on the diet of an endangered avian top predator in the northern Andes

Juan Sebastián Restrepo-Cardona
Sebastián Kohn
Vanessa Hull
ResearchOpen Access06 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Sex affects the nestling diet of a large aerial predator of the Andes

Juan Sebastián Restrepo-Cardona
Sebastián Kohn
Vanessa Hull
ResearchOpen Access09 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Decoding the Peruvian Amazon with in situ DNA barcoding of vertebrate and plant taxa

Pamela Sánchez-Vendizú
Gideon Erkenswick
Mrinalini Watsa
ResearchOpen Access01 Oct 2025
Scientific Data

Volume: 12, P: 1-15
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Correction: Corrigendum: Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells

Lorena Riol-Blanco
Cristina Delgado-Martín
José Luis Rodríguez-Fernández
Amendments and Corrections01 Jun 2010
Nature Immunology

Volume: 11, P: 543
A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism

Stephan Nopp
Clemens Spielvogel
H. M. Bui
ResearchOpen Access24 Sept 2025
Scientific Reports

Volume: 15, P: 1-12
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin

Cohesin, which tethers sister chromatids together, is found to be cleaved by separase after DNA damage, resulting in cohesin dissociation and allowing for post-replicative repair of DNA double-strand breaks.

Alexandra McAleenan
Andres Clemente-Blanco
Luis Aragón
Research25 Nov 2012
Nature

Volume: 493, P: 250-254
Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Clinical studies have suggested that the therapeutic potential of polyclonal convalescent plasma is highest in the first days of symptoms. Here, the authors present results from a pooled analysis of two clinical trials in COVID-19 outpatients that did not provide conclusive evidence in favor of convalescent plasma.

Pere Millat-Martinez
Arvind Gharbharan
Michael Marks
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-9
Seven-month kinetics of SARS-CoV-2 antibodies and role of pre-existing antibodies to human coronaviruses

Long-term characterisation of SARS-CoV-2 antibody kinetics is needed to understand the protective role of the immune response. Here the authors describe antibody levels and neutralisation activity in healthcare workers over seven months and investigate the role of immunity to endemic human coronaviruses.

Natalia Ortega
Marta Ribes
Carlota Dobaño
ResearchOpen Access06 Aug 2021
Nature Communications

Volume: 12, P: 1-10
Effects of squat training on energy expenditure, oxygen consumption, and heart rate in young healthy adults

Indya del-Cuerpo
Pedro Delgado-Floody
Luis Javier Chirosa-Ríos
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Food groups associated with immune-mediated inflammatory diseases: a Mendelian randomization and disease severity study

Antonio Julià
Sergio H. Martínez-Mateu
Adrià Aterido
Research23 Apr 2021
European Journal of Clinical Nutrition

Volume: 75, P: 1368-1382
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Membrane protein megahertz crystallography at the European XFEL

The European X-ray free-electron laser (EuXFEL) in Hamburg is the first XFEL with a megahertz repetition rate. Here the authors present the 2.9 Å structure of the large membrane protein complex Photosystem I from T. elongatus that was determined at the EuXFEL.

Chris Gisriel
Jesse Coe
Nadia A. Zatsepin
ResearchOpen Access04 Nov 2019
Nature Communications

Volume: 10, P: 1-11
The genetic ancestry of American Creole cattle inferred from uniparental and autosomal genetic markers

Catarina Ginja
Luis Telo Gama
Amparo Martinez
ResearchOpen Access07 Aug 2019
Scientific Reports

Volume: 9, P: 1-16
Light echoes from ancient supernovae in the Large Magellanic Cloud

Armin Rest
Nicholas B. Suntzeff
Christopher Stubbs
Research22 Dec 2005
Nature

Volume: 438, P: 1132-1134
Antibody engineering: facing new challenges in cancer therapy

Laura Sanz
Ángel M Cuesta
Luis Álvarez-Vallina
Reviews01 Jun 2005
Acta Pharmacologica Sinica

Volume: 26, P: 641-648
Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination

Giacomo De Piccoli
Felipe Cortes-Ledesma
Luis Aragón
Research06 Aug 2006
Nature Cell Biology

Volume: 8, P: 1032-1034
Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance

Myelomagenesis progresses through well-defined pre-malignant states. Here, using single-cell RNA sequencing and T cell receptor repertoire analysis of bone marrow T cells in patients at different stages of myelomagenesis, the authors identify large clonotypic expansions characterized by the expression of multiple immune checkpoints.

Cirino Botta
Cristina Perez
Bruno Paiva
ResearchOpen Access20 Sept 2023
Nature Communications

Volume: 14, P: 1-15
Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection

Pérez et al. evaluate whether antibody levels and neutralization titers correlate with protection against SARS-CoV-2, including Omicron sub-variants BQ.1 and XBB, in a cohort of Spanish healthcare workers. They find an association that wanes over time, highlighting the need for updated vaccination strategies.

Carla Martín Pérez
Anna Ramírez-Morros
Carlota Dobaño
ResearchOpen Access20 Jun 2025
Communications Medicine

Volume: 5, P: 1-13
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models

Reversible mitochondrial stress leading to improved mitochondrial function (mitohormesis) has been reported as an anti-aging mechanism. Here the authors report that harmol (a beta-carboline compound) induces mitohormesis in peripheral organs, alleviates aging-related phenotypes in mice, and extends lifespan in invertebrate models.

Luis Filipe Costa-Machado
Esther Garcia-Dominguez
Pablo J. Fernandez-Marcos
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-22
Beyond the effects of HIV infection and integrase inhibitors-based therapies on oral bacteriome

Pablo Villoslada-Blanco
Patricia Pérez-Matute
José A. Oteo
ResearchOpen Access31 Aug 2023
Scientific Reports

Volume: 13, P: 1-8
Sequencing of diverse mandarin, pummelo and orange genomes reveals complex history of admixture during citrus domestication

Genome sequences of nine species of citrus, including oranges, pummelos and mandarins, reveal pathways of domestication and provide resources for breeding.

G Albert Wu
Simon Prochnik
Daniel Rokhsar
ResearchOpen Access08 Jun 2014
Nature Biotechnology

Volume: 32, P: 656-662
CARDIOVASCULAR EFFECTS OF AIRWAY SUCTIONING IN INFANTS WITH H.M.D. ON ASSISTED VENTILATION

Luis A Cabal
Bijan Siassi
Paul F Wehrle
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 444
Author Correction: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Pere Millat-Martinez
Arvind Gharbharan
Michael Marks
Amendments and CorrectionsOpen Access22 May 2024
Nature Communications

Volume: 15, P: 1
Personalized federated learning for predicting disability progression in multiple sclerosis using real-world routine clinical data

Ashkan Pirmani
Edward De Brouwer
Yves Moreau
ResearchOpen Access24 Jul 2025
npj Digital Medicine

Volume: 8, P: 1-15
PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes

Helena Sardà
Cristina Colom
Antonio Pérez
ResearchOpen Access26 Mar 2024
Scientific Reports

Volume: 14, P: 1-8
Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells

Immunological synapses (IS) involving surface receptors form between dendritic cells (DC) and T cells. Rodriguez-Fernandez and colleagues show that IS-induced signals activate Akt and NF-κB and suppress Foxo1 to promote DC survival.

Lorena Riol-Blanco
Cristina Delgado-Martín
José Luis Rodríguez-Fernández
Research07 Jun 2009
Nature Immunology

Volume: 10, P: 753-760
Cdc14 inhibits transcription by RNA polymerase I during anaphase

The mitotic regulator Cdc14 is shown to mediate transcriptional silencing of yeast ribosomal genes by preventing the nucleolar localization of a subunit of RNA polymerase I. If ribosomal transcription is not shut down, the presence of transcripts prevents the loading of condensin and blocks chromosome condensation and segregation.

Andrés Clemente-Blanco
María Mayán-Santos
Luis Aragón
Research21 Jan 2009
Nature

Volume: 458, P: 219-222
Hydrographic shifts in coastal waters reflect climate-driven changes in hydrological regimes across Northwestern Patagonia

Jorge León-Muñoz
Rodrigo Aguayo
Doris Soto
ResearchOpen Access04 Sept 2024
Scientific Reports

Volume: 14, P: 1-16
A formal analysis of Listeria monocytogenes cross-contamination dynamics in multi-species biofilms

Raquel A. Nogueira
Juan J. Rodríguez-Herrera
Marta L. Cabo
ResearchOpen Access08 Aug 2025
npj Science of Food

Volume: 9, P: 1-11
Cloxacillin plus fosfomycin versus cloxacillin alone for methicillin-susceptible Staphylococcus aureus bacteremia: a randomized trial

New treatments are essential for methicillin-susceptible Staphylococcus aureus bacteremia, but progress is slow. In this phase III–IV trial, cloxacillin plus fosfomycin failed to show superiority over cloxacillin alone, underscoring the challenges to improving patient outcomes.

Sara Grillo
Miquel Pujol
Ana Maria Sanchez-Diaz
ResearchOpen Access02 Oct 2023
Nature Medicine

Volume: 29, P: 2518-2525
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Ian Blair and colleagues use genome-wide linkage analysis and whole exome sequencing to identify mutations in the CCNF gene in large cohorts of amyotrophic lateral sclerosis and frontotemporal dementia patients. In addition to validating the mutations in international cohorts, the authors also show that mutant CCNFgene product affects ubiquitination and protein degradation in cultured cells.

Kelly L. Williams
Simon Topp
Ian P. Blair
ResearchOpen Access15 Apr 2016
Nature Communications

Volume: 7, P: 1-8
Proton stopping measurements at low velocity in warm dense carbon

Charged particle interaction and energy dissipation in plasma is fundamentally interesting. Here the authors study proton stopping in laser-produced plasma for the moderate to strong coupling with electrons.

S. Malko
W. Cayzac
L. Volpe
ResearchOpen Access24 May 2022
Nature Communications

Volume: 13, P: 1-12
Green synthesis of silver nanoparticles using Lysiloma acapulcensis exhibit high-antimicrobial activity

Diana Garibo
Hugo A. Borbón-Nuñez
Arturo Susarrey-Arce
ResearchOpen Access30 Jul 2020
Scientific Reports

Volume: 10, P: 1-11
Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

T. Sunn Pedersen
M. Otte
Sandor Zoletnik
ResearchOpen Access30 Nov 2016
Nature Communications

Volume: 7, P: 1-10
Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8⁺β7 integrin⁺ T cells and anti-SARS-CoV-2 IgA response

Post-acute sequelae SARS-CoV-2 (PASC), also known as long COVID is a chronic and often debilitating condition that develops following acute disease. Here authors show that individuals who suffer from PASC symptoms at six month following infection are characterized by persisting immunological disfunction, affecting cellular and humoral components of mucosal immunity.

André Santa Cruz
Ana Mendes-Frias
Ricardo Silvestre
ResearchOpen Access30 Mar 2023
Nature Communications

Volume: 14, P: 1-14

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