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Showing 1–15 of 15 results
Advanced filters: Author: Luis Ceze Clear advanced filters

  • The physical limits and reliability of PCR-based random access of DNA encoded data is unknown. Here the authors demonstrate reliable file recovery from as few as ten copies per sequence, providing a data density limit of 17 exabytes per gram.

    • Lee Organick
    • Yuan-Jyue Chen
    • Luis Ceze
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-7

  • DNA as a high density storage medium is receiving increasing attention, but long term physical storage is an unsolved problem. Here the authors show that up to 1 TB of data stored as dehydrated DNA spots on a glass cartridge can be retrieved in a spot of water using digital microfluidics with minimal data loss and contamination.

    • Sharon Newman
    • Ashley P. Stephenson
    • Luis Ceze
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-6

  • Synthetic DNA is the basis for promising technologies in data storage, barcoding, computing 62 and sercurity. In this review, the authors provide an overview of the field and its future.

    • Linda C. Meiser
    • Bichlien H. Nguyen
    • Robert N. Grass
    ReviewsOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Throughout evolution, DNA has been the primary medium of biological information storage. In this article, Ceze, Nivala and Strauss discuss how DNA can be adopted as a storage medium for custom data, as a potential future complement to current data storage media such as computer hard disks, optical disks and tape. They discuss strategies for coding, decoding and error correction and give examples of implementation both in vitro and in vivo.

    • Luis Ceze
    • Jeff Nivala
    • Karin Strauss
    Reviews
    Nature Reviews Genetics
    Volume: 20, P: 456-466

  • Toe-hold-mediated strand displacement (DSD) is a widely used molecular tool in applications such as DNA computing and nucleic acid diagnostics. Here the authors characterize dozens of orthogonal barcode sequences that can be used for monitoring the output kinetics of multiplexed DSD reactions in real-time using a commercially-available portable nanopore array device.

    • Karen Zhang
    • Yuan-Jyue Chen
    • Jeff Nivala
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Storage technology based on DNA is emerging as an information dense and durable medium. Here the authors use machine learning-based encoding and hybridization probes to execute similarity searches in a DNA database.

    • Callista Bee
    • Yuan-Jyue Chen
    • Luis Ceze
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • DNA is an attractive digital data storing medium due to high information density and longevity. Here the authors use millions of sequences to investigate inherent biases in DNA synthesis and PCR amplification.

    • Yuan-Jyue Chen
    • Christopher N. Takahashi
    • Karin Strauss
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • 200 MB of digital data is stored in DNA, randomly accessed and recovered using an error-free approach.

    • Lee Organick
    • Siena Dumas Ang
    • Karin Strauss
    Research
    Nature Biotechnology
    Volume: 36, P: 242-248

  • A major bottleneck in using DNA as a data storage medium is the slowness of sequencing. Here the authors decode 1.67 megabytes of information using a portable nanopore platform with an assembly strategy for increased throughput.

    • Randolph Lopez
    • Yuan-Jyue Chen
    • Luis Ceze
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9