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Advanced filters: Author: Luis I. Gutierrez-Rus Clear advanced filters

  • Family 1 glycosidases (GH1) are present in the three domains of life and share classical TIM-barrel fold. Structural and biochemical analyses of a resurrected ancestral GH1 enzyme reveal heme binding, not known in its modern descendants. Heme rigidifies the TIM-barrel and allosterically enhances catalysis.

    • Gloria Gamiz-Arco
    • Luis I. Gutierrez-Rus
    • Jose M. Sanchez-Ruiz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16