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Showing 1–3 of 3 results
Advanced filters: Author: Luis P. Kuschel Clear advanced filters

  • MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas, one driven by local enhancers and the other by hijacking of distal regulatory elements.

    • Konstantin Helmsauer
    • Maria E. Valieva
    • Richard P. Koche
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The Leica SP8 FALCON (FAst Lifetime CONtrast) is a fast and completely integrated fluorescence lifetime imaging microscopy (FLIM) confocal platform. SP8 FALCON delivers video-rate FLIM with pixel-by-pixel quantification, thanks to a novel concept for measuring fluorescence lifetimes built on fast electronics and sensitive spectral hybrid detectors. Photon arrival times are recorded at count rates typical for standard confocal imaging. The system has ultra-short dead time and powerful built-in algorithms for data acquisition and analysis. The deep integration of FLIM into the confocal platform provides easy access to complex FLIM experiments.

    • Luis A. J. Alvarez
    • Bernd Widzgowski
    • Frank Hecht
    Advertorial
    Nature Research Custom