Nature Search

Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

Ada Eban-Rothschild
Lior Appelbaum
Luis de Lecea
Reviews05 Dec 2017
Neuropsychopharmacology

Volume: 43, P: 937-952
A cortical neuropeptide with neuronal depressant and sleep-modulating properties

Luis de Lecea
José R. Criado
J. Gregor Sutcliffe
Research16 May 1996
Nature

Volume: 381, P: 242-245
Cortistatin: not just another somatostatin analog

Cortistatin is a member of the somatostatin family of peptide hormones. Although cortistatin and somatostatin display many structural and functional similarities, there are also notable differences including tissue distribution and receptor selectivity. This Viewpoint describes how these differences might reflect novel actions of cortistatin in the brain and immune system.

Luis de Lecea
Justo P Castaño
Reviews01 Jul 2006
Nature Clinical Practice Endocrinology & Metabolism

Volume: 2, P: 356-357
Circuit-breakers: optical technologies for probing neural signals and systems

Newly emerging techniques will revolutionize our understanding of the mammalian brain. Deisseroth and colleagues detail the development and use of microbial opsins as optogenetic tools for the study of neural circuits and discuss the use of these tools as potential future therapies for neurological disorders.

Feng Zhang
Alexander M. Aravanis
Karl Deisseroth
Reviews01 Aug 2007
Nature Reviews Neuroscience

Volume: 8, P: 577-581
Aging and injury drive neuronal senescence in the dorsal root ganglia

The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.

Lauren J. Donovan
Chelsie L. Brewer
Vivianne L. Tawfik
ResearchOpen Access14 May 2025
Nature Neuroscience

Volume: 28, P: 985-997
Erratum: Circuit-breakers: optical technologies for probing neural signals and systems

Feng Zhang
Alexander M. Aravanis
Karl Deisseroth
Amendments and Corrections01 Sept 2007
Nature Reviews Neuroscience

Volume: 8, P: 732
Sleep disruption impairs haematopoietic stem cell transplantation in mice

How can you increase the success of hematopoietic stem cell (HSC) transplantation? In mice, Rolls et al. identify sleep in the donor as an important factor, finding that less sleep leads to 50% lower HSC engraftment, via miR-19b and suppressor of cytokine signaling genes, which prevent HSC homing.

Asya Rolls
Wendy W. Pang
Luis de Lecea
Research14 Oct 2015
Nature Communications

Volume: 6, P: 1-9
Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states

Using genetically encoded physiological tools for monitoring, manipulating, and mapping discrete neural circuits, Giardino et al. characterize 2 discrete amygdala→hypothalamus pathways that promote opposite behavioral responses to emotional stimuli.

William J. Giardino
Ada Eban-Rothschild
Luis de Lecea
Research23 Jul 2018
Nature Neuroscience

Volume: 21, P: 1084-1095
Tuning arousal with optogenetic modulation of locus coeruleus neurons

Using optogenetic tools, Carter et al. find a frequency-dependent causal relationship between locus coeruleus firing, sleep-to-wake transitions and locomotor arousal in mice.

Matthew E Carter
Ofer Yizhar
Luis de Lecea
Research31 Oct 2010
Nature Neuroscience

Volume: 13, P: 1526-1533
In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

Neurons of the locus coeruleus (LC) are implicated in attention and arousal. Here the authors use CRISPR/Cas9 to disrupt dopamine beta hydroxylase in LC neurons and see this reduces LC-evoked sleep-to-wake transitions and wake length.

Hiroshi Yamaguchi
F. Woodward Hopf
Luis de Lecea
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-8
Adolescent sleep shapes social novelty preference in mice

Bian et al. show that sleep during adolescence is crucial for shaping the preference for novel social stimulation in adulthood. This developmental role of sleep is mediated by balanced levels of VTA activity during adolescent brain development.

Wen-Jie Bian
Chelsie L. Brewer
Luis de Lecea
Research26 May 2022
Nature Neuroscience

Volume: 25, P: 912-923
Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

Detailed insight into how the brain responds to Trypanosoma brucei infection is lacking. Here, single cell and spatial transcriptomics are integrated to characterise this response, identifying a unique crosstalk between microglia and plasma cells.

Juan F. Quintana
Praveena Chandrasegaran
Annette MacLeod
ResearchOpen Access30 Sept 2022
Nature Communications

Volume: 13, P: 1-19
Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

The hypothalamic-pituitary-adrenal axis coordinates behavioral and physiological responses to stress but the mechanisms are poorly understood. Here, the authors show that neurons that produce hypocretin/orexin in the lateral hypothalamic area regulate corticosterone release and a variety of behaviors related to the stress response.

Patricia Bonnavion
Alexander C. Jackson
Luis de Lecea
ResearchOpen Access19 Feb 2015
Nature Communications

Volume: 6, P: 1-14
VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors

Motivated behaviors are critically dependent upon arousal but little is known about the neuronal mechanisms that coordinate motivational processes with sleep–wake regulation. The authors demonstrate that VTA dopaminergic neurons, which are central regulators of motivational processes, bidirectionally regulate sleep–wake states and sleep-related nesting behavior.

Ada Eban-Rothschild
Gideon Rothschild
Luis de Lecea
Research05 Sept 2016
Nature Neuroscience

Volume: 19, P: 1356-1366
Not asleep, not quite awake

Narcoleptic individuals experience episodes of cataplexy, in which they retain consciousness but have no muscle tone. Consciousness and muscle tone are controlled by distinct brain regions, now delineated by research on narcoleptic dogs.

J Gregor Sutcliffe
Luis de Lecea
News & Views01 Jul 2004
Nature Medicine

Volume: 10, P: 673-674
The hypocretins: Setting the arousal threshold

J. Gregor Sutcliffe
Luis de Lecea
Reviews01 May 2002
Nature Reviews Neuroscience

Volume: 3, P: 339-348
Neural substrates of awakening probed with optogenetic control of hypocretin neurons

Antoine R. Adamantidis
Feng Zhang
Luis de Lecea
Research17 Oct 2007
Nature

Volume: 450, P: 420-424
Molecular characterization of multidrug resistant Enterobacterales strains isolated from liver and kidney transplant recipients in Spain

Marta Fernández-Martínez
Claudia González-Rico
Elena Resino
ResearchOpen Access04 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Cell type specific focused ultrasound neuromodulation in preclinical models of sleep and psychiatric disorders

Keith R. Murphy
Luis de Lecea
Research18 Jul 2023
Neuropsychopharmacology

Volume: 49, P: 299-300
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

Feng Zhang
Viviana Gradinaru
Karl Deisseroth
Protocols18 Feb 2010
Nature Protocols

Volume: 5, P: 439-456
Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

Raúl M. Luque
José Cordoba-Chacon
Justo P. Castaño
ResearchOpen Access30 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice

Optogenetic or pharmacological modulation of hypocretin neurons impacts mouse impulsivity in a Go/No-Go task, suggesting that these neurons play a key role in integrating salient stimuli and guiding responses to various environmental cues.

Susan M. Tyree
Kimberly J. Jennings
Luis de Lecea
ResearchOpen Access19 Jan 2023
Communications Biology

Volume: 6, P: 1-8
In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model

Joseph M. Castellano
Mikael Palner
Tony Wyss-Coray
ResearchOpen Access01 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Sleep and neuropsychiatric illness

John W. Winkelman
Luis de Lecea
Editorial05 Sept 2019
Neuropsychopharmacology

Volume: 45, P: 1-2

Search

Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

A cortical neuropeptide with neuronal depressant and sleep-modulating properties

Cortistatin: not just another somatostatin analog

Circuit-breakers: optical technologies for probing neural signals and systems

Aging and injury drive neuronal senescence in the dorsal root ganglia

Erratum: Circuit-breakers: optical technologies for probing neural signals and systems

Sleep disruption impairs haematopoietic stem cell transplantation in mice

Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states

Tuning arousal with optogenetic modulation of locus coeruleus neurons

In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

Adolescent sleep shapes social novelty preference in mice

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses

VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors

Not asleep, not quite awake

The hypocretins: Setting the arousal threshold

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

Molecular characterization of multidrug resistant Enterobacterales strains isolated from liver and kidney transplant recipients in Spain

Cell type specific focused ultrasound neuromodulation in preclinical models of sleep and psychiatric disorders

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice

In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model

Sleep and neuropsychiatric illness

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