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Showing 1–2 of 2 results
Advanced filters: Author: Luis-Jaime Castro-Vega Clear advanced filters

  • Pheochromocytomas and paragangliomas (PCCs/PGLs) are rare neuroendocrine tumours with a significant genetic component. Here, the authors carry out a multi-omic integrative characterization of PCC/PGL and reveal potential genomic alterations and regulatory mechanisms involved in the disease.

    • Luis Jaime Castro-Vega
    • Eric Letouzé
    • Anne-Paule Gimenez-Roqueplo
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9

  • Evidence suggests that the TCA cycle enzyme complex succinate dehydrogenase (SDH) may be dispensable for cell proliferation in some cancer cells. Here the authors show that SDH deficient cells become dependent on the mitochondrial enzyme pyruvate carboxylase for aspartate production and proliferation.

    • Charlotte Lussey-Lepoutre
    • Kate E. R. Hollinshead
    • Daniel A. Tennant
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-9