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CD169⁺ macrophages take the bullet

Lifting the protective shield provided by the type I interferon system selectively in CD169⁺ splenic macrophages enforces localized viral replication. Such controlled release of virus amplifies adaptive antiviral immune responses.

Burkhard Ludewig
Luisa Cervantes-Barragan
News & Views16 Dec 2011
Nature Immunology

Volume: 13, P: 13-14
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

The biological role of 2′-O-methylation of host and viral mRNA has remained elusive. Thiel and co-workers show that this modification modulates the induction of type I interferon and sensitivity to interferon.

Roland Züst
Luisa Cervantes-Barragan
Volker Thiel
Research09 Jan 2011
Nature Immunology

Volume: 12, P: 137-143
Aggravation of viral hepatitis by platelet-derived serotonin

Philipp A Lang
Claudio Contaldo
Karl S Lang
Research30 May 2008
Nature Medicine

Volume: 14, P: 756-761
SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Colonna and colleagues generate mice in which both type 1 innate lymphoid cells and natural killer cells selectively lack SMAD4, which promotes canonical signaling of all cytokines of the TGF-β family. Unexpectedly, SMAD4 deficiency does not visibly affect the differentiation of type 1 innate lymphoid cells but instead alters the phenotype of conventional natural killer cells.

Victor S Cortez
Tyler K Ulland
Marco Colonna
Research31 Jul 2017
Nature Immunology

Volume: 18, P: 995-1003

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CD169+ macrophages take the bullet

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

Aggravation of viral hepatitis by platelet-derived serotonin

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

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CD169⁺ macrophages take the bullet