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Showing 1–4 of 4 results
Advanced filters: Author: Luisa Morales-Nebreda Clear advanced filters

  • Analysis of bronchoalveolar lavage fluid samples from patients with SARS-CoV-2-induced respiratory failure suggests that SARS-CoV-2 infects alveolar macrophages to cause release of T cell chemoattractants, thereby inducing local inflammatory cytokine release and further T cell activation, ultimately resulting in a positive feedback loop that drives alveolar inflammation.

    • Rogan A. Grant
    • Luisa Morales-Nebreda
    • Ziyou Ren
    Research
    Nature
    Volume: 590, P: 635-641

  • Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

    • Nikolay S. Markov
    • Ziyou Ren
    • Brian White
    Research
    Nature Immunology
    Volume: 25, P: 1607-1622

  • The mechanism of NLRP3 activation remains incompletely characterized. Here the authors show that it is dependent on vimentin, and that NLRP3-mediated lung injury and fibrosis induced by endotoxin, asbestos or bleomycin are reduced in vimentin-deficient mice.

    • Gimena dos Santos
    • Micah R. Rogel
    • Karen M. Ridge
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • Systemic sclerosis (SSc) is a fibrotic disease affecting multiple organs. Here the authors use patient samples plus mouse studies to show a central role for tenascin C as a TLR4 activator responsible for persistence of fibrosis in the context of SSc and SSc-like disease.

    • Swati Bhattacharyya
    • Wenxia Wang
    • John Varga
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14