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Showing 1–3 of 3 results
Advanced filters: Author: Luiz F. M. Passalacqua Clear advanced filters

  • Fluorogenic RNA aptamers such as Mango are powerful tools for RNA imaging. An ultrabright RNA-activated fluorophore with improved photophysical performance has now been developed using a structure-informed, fragment-based screening approach. This system was studied using high-resolution crystallography and applied to image RNA in cells.

    • Mo Yang
    • Peri R. Prestwood
    • John S. Schneekloth Jr
    Research
    Nature Chemistry
    Volume: 17, P: 1188-1195

  • The recently discovered aptamer Beetroot is a homodimeric RNA that binds and activates DFAME, a conditional, red-shifted fluorophore derived from GFP. Here the authors determine the Beetroot-DFAME co-crystal structure, which is distinctively different from that of similar RNA aptamer Corn.

    • Luiz F. M. Passalacqua
    • Mary R. Starich
    • Adrian R. Ferré-D’Amaré
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • X-ray crystallography and cryo-electron microscopy analyses of Lettuce—a DNA mimic of GFP—bound to various fluorophores reveal previously unknown structures of DNA that rival analogous RNAs in complexity.

    • Luiz F. M. Passalacqua
    • Michael T. Banco
    • Adrian R. Ferré-D’Amaré
    Research
    Nature
    Volume: 618, P: 1078-1084