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Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

Pulmonary carcinoids account for about 2% of pulmonary neoplasms. Here, the authors carry out gene copy number analysis, genome/exome, and transcriptome sequencing of pulmonary carcinoids and identify frequent mutations in chromatin-remodelling genes that can drive tumorigenesis in these tumours.

Lynnette Fernandez-Cuesta
Martin Peifer
Roman K. Thomas
Research27 Mar 2014
Nature Communications

Volume: 5, P: 1-7
Comprehensive genomic profiles of small cell lung cancer

Genomic sequencing of 110 human small cell lung cancers identifies genomic signatures including nearly ubiquitous bi-allelic inactivation of TP53 and RB1, a role for NOTCH family genes, and somatic rearrangements that create an oncogenic version of TP73.

Julie George
Jing Shan Lim
Roman K. Thomas
Research13 Jul 2015
Nature

Volume: 524, P: 47-53
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

Jan Molenaar and colleagues show that LIN28B is overexpressed and amplified in human neuroblastomas and that LIN28B regulates let-7 family miRNAs and MYCN. They create a transgenic mouse model of LIN28B overexpression and show that these mice develop neuroblastoma tumors.

Jan J Molenaar
Raquel Domingo-Fernández
Johannes H Schulte
Research07 Oct 2012
Nature Genetics

Volume: 44, P: 1199-1206
Mutational dynamics between primary and relapse neuroblastomas

Alexander Schramm, Johannes Schulte and colleagues characterize 16 paired samples from patients with neuroblastoma at diagnosis and relapse using whole-exome sequencing, mRNA expression profiling, array CGH and DNA methylation analysis. Their data show the frequency, identity and evolution of genetic alterations in neuroblastoma.

Alexander Schramm
Johannes Köster
Johannes H Schulte
Research29 Jun 2015
Nature Genetics

Volume: 47, P: 872-877
Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer

Activation of the insulin-like growth factor 1 receptor may underlie clinical resistance to inhibition of the anaplastic lymphoma receptor kinase in lung cancer.

Christine M Lovly
Nerina T McDonald
William Pao
Research31 Aug 2014
Nature Medicine

Volume: 20, P: 1027-1034
Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

Hans-Ulrich Schildhaus
Lukas C Heukamp
Reinhard Buettner
ResearchOpen Access08 Jun 2012
Modern Pathology

Volume: 25, P: 1473-1480
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Roman Thomas and colleagues report exome sequencing of 29 small-cell lung cancers (SCLCs), 2 SCLC genomes and transcriptomes of 15 SCLCs. They identify recurrent mutations in the CREBBP, EP300 and MLL genes encoding histone modifiers. They identify mutations in SLIT2 and EPHA7, which have a role in axon guidance and cell migration, and focal amplifications of FGFR1.

Martin Peifer
Lynnette Fernández-Cuesta
Roman K Thomas
Research02 Sept 2012
Nature Genetics

Volume: 44, P: 1104-1110
Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas

Andreas H Scheel
Manfred Dietel
Reinhard Buettner
Research08 Jul 2016
Modern Pathology

Volume: 29, P: 1165-1172
ALK ^G1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

Sebastian Y. F. Michels
Andreas H. Scheel
Jürgen Wolf
ResearchOpen Access20 Mar 2017
npj Precision Oncology

Volume: 1, P: 1-4
The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production

Felix Tolksdorf
Julita Mikulec
Linda Diehl
ResearchOpen Access31 Oct 2018
Scientific Reports

Volume: 8, P: 1-9
LIN28B enhanced tumorigenesis in an autochthonous KRAS^G12V-driven lung carcinoma mouse model

Lydia Meder
Katharina König
Roland T. Ullrich
Research05 Mar 2018
Oncogene

Volume: 37, P: 2746-2756
Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group

Claudia Vollbrecht
Robert Werner
Fabian Dominik Mairinger
ResearchOpen Access08 Dec 2015
British Journal of Cancer

Volume: 113, P: 1704-1711

Search

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

Comprehensive genomic profiles of small cell lung cancer

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

Mutational dynamics between primary and relapse neuroblastomas

Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas

ALK ^G1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production

LIN28B enhanced tumorigenesis in an autochthonous KRAS^G12V-driven lung carcinoma mouse model

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group

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