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Showing 1–14 of 14 results
Advanced filters: Author: Lukas Lomb Clear advanced filters

  • Many cancers metastasize to the lungs, yet immune cells rarely succeed in eliminating them. Here we show that although NK cells that patrol the lung vasculature are highly differentiated and cytotoxic to circulating tumor cells, these fail to access extravasated lesions, while NK cells that infiltrate the tumor parenchyma are less differentiated, exhibit poor cytotoxicity functionally restrained by TGF-β, allowing metastatic tumors to persist.

    • Marijne Vermeer
    • Colin Sparano
    • Sònia Tugues
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Lipidic sponge phase crystallization yields membrane protein microcrystals that can be injected into an X-ray free electron laser beam, yielding diffraction patterns that can be processed to recover the crystal structure.

    • Linda C Johansson
    • David Arnlund
    • Richard Neutze
    Research
    Nature Methods
    Volume: 9, P: 263-265

  • Researchers describe a mechanism capable of compressing fast and intense X-ray pulses through the rapid loss of crystalline periodicity. It is hoped that this concept, combined with X-ray free-electron laser technology, will allow scientists to obtain structural information at atomic resolutions.

    • Anton Barty
    • Carl Caleman
    • Henry N. Chapman
    Research
    Nature Photonics
    Volume: 6, P: 35-40

  • Serial femtosecond crystallography is an X-ray free-electron-laser-based method that uses X-ray bursts to determine protein structures. Here the authors present the structure of a photosynthetic reaction centre, an integral membrane protein, achieved with no sign of X-ray-induced radiation damage.

    • Linda C. Johansson
    • David Arnlund
    • Richard Neutze
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-7

  • Defects can significantly alter the physical properties of materials. A detailed experimental analysis of defects in carbon nanotubes enables the relationship between the atomic response and the broadly available macrosopic behaviour to be captured.

    • Indhira O. Maciel
    • Neil Anderson
    • Ado Jorio
    Research
    Nature Materials
    Volume: 7, P: 878-883

  • The start-up of the new femtosecond hard X-ray laser facility in Stanford, the Linac Coherent Light Source, has brought high expectations for a new era for biological imaging. The intense, ultrashort X-ray pulses allow diffraction imaging of small structures before radiation damage occurs. This new capability is tested for the problem of structure determination from nanocrystals of macromolecules that cannot be grown in large crystals. Over three million diffraction patterns were collected from a stream of nanocrystals of the membrane protein complex photosystem I, which allowed the assembly of a three-dimensional data set for this protein, and proves the concept of this imaging technique.

    • Henry N. Chapman
    • Petra Fromme
    • John C. H. Spence
    Research
    Nature
    Volume: 470, P: 73-77

  • The start-up of the new femtosecond hard X-ray laser facility in Stanford, the Linac Coherent Light Source, has brought high expectations for a new era for biological imaging. The intense, ultrashort X-ray pulses allow diffraction imaging of small structures before radiation damage occurs. This new capability is tested for the problem of imaging a non-crystalline biological sample. Images of mimivirus are obtained, the largest known virus with a total diameter of about 0.75 micrometres, by injecting a beam of cooled mimivirus particles into the X-ray beam. The measurements indicate no damage during imaging and prove the concept of this imaging technique.

    • M. Marvin Seibert
    • Tomas Ekeberg
    • Janos Hajdu
    Research
    Nature
    Volume: 470, P: 78-81

  • Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.

    • Kavita Praveen
    • Gaurang C. Patel
    • Giovanni Coppola
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15

  • Femtosecond X-ray pulses were used to obtain diffraction data on photosystem II, revealing conformational changes as the complex transitions from the dark S1 state to the double-pumped S3 state; the time-resolved serial femtosecond crystallography technique enables structural determination of protein conformations that are highly prone to traditional radiation damage.

    • Christopher Kupitz
    • Shibom Basu
    • Petra Fromme
    Research
    Nature
    Volume: 513, P: 261-265