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PD-1 is requisite for skin T_RM cell formation and specification by TGFβ

Anandasabapathy and colleagues show that the inhibitory receptor PD-1 impacts the specification of tissue-resident memory T cells in the skin.

K. Sanjana P. Devi
Eric Wang
Niroshana Anandasabapathy
ResearchOpen Access29 Jul 2025
Nature Immunology

Volume: 26, P: 1339-1351
Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

Dwaine F. Emerich
Shelley R. Winn
Jeffrey H. Kordower
Research27 Mar 1997
Nature

Volume: 386, P: 395-399
Runx3 drives a CD8⁺ T cell tissue residency program that is absent in CD4⁺ T cells

Mackay and colleagues show that distinct programs of tissue residency are induced in CD8⁺ and CD4⁺ T_RM cell subsets, a difference attributable to the activity of the transcription factor Runx3.

Raíssa Fonseca
Thomas N. Burn
Laura K. Mackay
Research26 Jul 2022
Nature Immunology

Volume: 23, P: 1236-1245
Removing unwanted variation from large-scale RNA sequencing data with PRPS

Cancer RNA-seq data are normalized with respect to library size, tumor purity and batch effects.

Ramyar Molania
Momeneh Foroutan
Terence P. Speed
ResearchOpen Access15 Sept 2022
Nature Biotechnology

Volume: 41, P: 82-95
Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Tissue-resident memory T (T_RM) cells are distributed throughout the body as relatively sessile populations. Mackay and colleagues find that the tissue in which T_RM cells are generated dictates their properties and is in turn defined according to T_RM-cell-intrinsic sensitivity to signaling via the cytokine TGFβ.

Susan N. Christo
Maximilien Evrard
Laura K. Mackay
Research23 Aug 2021
Nature Immunology

Volume: 22, P: 1140-1151
Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

Dawson et al. characterize a macrophage population associated with mammary ducts that are long lived, derive from embryonic precursors and have multiple roles in pregnancy, lactation, involution and cancer.

Caleb A. Dawson
Bhupinder Pal
Jane E. Visvader
Research27 Apr 2020
Nature Cell Biology

Volume: 22, P: 546-558

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PD-1 is requisite for skin TRM cell formation and specification by TGFβ

Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells

Removing unwanted variation from large-scale RNA sequencing data with PRPS

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling

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PD-1 is requisite for skin T_RM cell formation and specification by TGFβ

Runx3 drives a CD8⁺ T cell tissue residency program that is absent in CD4⁺ T cells