Nature Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Increased reservoir ages and poorly ventilated deep waters inferred in the glacial Eastern Equatorial Pacific

Accurate deep Pacific Ocean ventilation ages are hindered by poor surface reservoir age reconstructions. Here, the authors generate new ventilation ages for the deep waters of the Eastern Equatorial Pacific, which indicate reduced air-sea gas exchange during the last glacial.

Maria de la Fuente
Luke Skinner
Isabel Cacho
ResearchOpen Access03 Jul 2015
Nature Communications

Volume: 6, P: 1-11
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Muted change in Atlantic overturning circulation over some glacial-aged Heinrich events

Several periods of massive iceberg discharge into the North Atlantic and widespread cooling marked the last glacial period. Reconstructions of northward flow along the Florida margin suggest that not all cold events were associated with a change in the strength of the Atlantic meridional overturning circulation.

Jean Lynch-Stieglitz
Matthew W. Schmidt
Ping Chang
Research12 Jan 2014
Nature Geoscience

Volume: 7, P: 144-150
Extreme deepening of the Atlantic overturning circulation during deglaciation

The termination of the last glacial period was punctuated by the collapse and resumption of Atlantic meridional overturning circulation. Sedimentary records from the South Atlantic Ocean indicate that an unusually deep limb of North Atlantic Deep Water formed after the resumption of overturning circulation during the Bølling–Allerød warm event.

Stephen Barker
Gregor Knorr
Luke C. Skinner
Research25 Jul 2010
Nature Geoscience

Volume: 3, P: 567-571
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Author Correction: MEF2C regulates NK cell effector functions through control of lipid metabolism

Joey H. Li
Adalia Zhou
Timothy E. O’Sullivan
Amendments and Corrections19 Apr 2024
Nature Immunology

Volume: 25, P: 928
Conjunctival involvement in malignancy-associated acanthosis nigricans

H Tabandeh
S Gopal
N Dilly
Research01 Sept 1993
Eye

Volume: 7, P: 648-651
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
MEF2C regulates NK cell effector functions through control of lipid metabolism

Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans. This control is exerted via regulation of lipid metabolism, and deficiency in MEF2C can be overcome by oleic acid supplementation.

Joey H. Li
Adalia Zhou
Timothy E. O’Sullivan
Research08 Apr 2024
Nature Immunology

Volume: 25, P: 778-789
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Abrupt changes in the southern extent of North Atlantic Deep Water during Dansgaard–Oeschger events

The last glacial period was characterized by a series of abrupt climate changes. An analysis of bottom water chemistry in the South Atlantic suggests that the southern extent of North Atlantic Deep Water was reduced during abrupt coolings.

Julia Gottschalk
Luke C. Skinner
Axel Timmermann
Research12 Oct 2015
Nature Geoscience

Volume: 8, P: 950-954
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Xueya Zhou
Pamela Feliciano
Wendy K. Chung
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1305-1319
Deep-water circulation changes lead North Atlantic climate during deglaciation

The response time of North Atlantic climate to changes in high-latitude deep-water formation during the last deglaciation is still unclear. Here the authors show that gradual changes in Nordic Seas deep-water circulation systematically lead ahead of abrupt regional climate shifts by ~400 years.

Francesco Muschitiello
William J. D’Andrea
Trond M. Dokken
ResearchOpen Access20 Mar 2019
Nature Communications

Volume: 10, P: 1-10
Transient hydrodynamic effects influence organic carbon signatures in marine sediments

Marine sedimentary records and the proxies within play a central role in unlocking our understanding of past climates, yet interpreting the signals they contain can be complex. Here, the authors reveal and discuss the complex effects of hydrodynamics on carbon accumulation in the sediments off the Iberian margin.

Clayton R. Magill
Blanca Ausín
Timothy I. Eglinton
ResearchOpen Access08 Nov 2018
Nature Communications

Volume: 9, P: 1-8
Biological and physical controls in the Southern Ocean on past millennial-scale atmospheric CO₂ changes

Direct proxy evidence for the many explanations for past millennial-scale atmospheric CO₂ changes remains scarce. Here, the authors show that changes in the efficiency of respired carbon storage in the deep Southern Ocean were linked to variations in atmospheric CO₂over the last 65,000 years.

Julia Gottschalk
Luke C. Skinner
Claire Waelbroeck
ResearchOpen Access17 May 2016
Nature Communications

Volume: 7, P: 1-11
Exploring the perspectives of clinical professionals and support staff on implementing supported self-management for asthma in UK general practice: an IMP²ART qualitative study

Susan Morrow
Luke Daines
Hilary Pinnock
ResearchOpen Access18 Jul 2017
npj Primary Care Respiratory Medicine

Volume: 27, P: 1-7
Optimizing practice scheduling requires quantitative tracking of individual item performance

Luke G. Eglington
Philip I. Pavlik Jr
ResearchOpen Access15 Oct 2020
npj Science of Learning

Volume: 5, P: 1-10
An ice–climate oscillatory framework for Dansgaard–Oeschger cycles

Large changes in Greenland and North Atlantic temperature — termed Dansgaard–Oeschger cycles — have been linked to variations in the strength of the Atlantic meridional overturning circulation. However, the mechanisms are debated. This Review proposes an oscillatory framework to explain Dansgaard–Oeschger cyclicity, involving atmosphere–ocean–ice interactions.

Laurie C. Menviel
Luke C. Skinner
Polychronis C. Tzedakis
Reviews03 Nov 2020
Nature Reviews Earth & Environment

Volume: 1, P: 677-693
Southern Ocean convection amplified past Antarctic warming and atmospheric CO₂ rise during Heinrich Stadial 4

Antarctic warming and the rise of atmospheric CO2 levels during Heinrich Stadial 4 were amplified by enhanced convection and air-sea gas and heat exchange in the Southern Ocean, according to an analysis of deep water ventilation and temperature proxies

Luke Skinner
Laurie Menviel
Mervyn Greaves
ResearchOpen Access22 Sept 2020
Communications Earth & Environment

Volume: 1, P: 1-8
Intensified summer monsoon and the urbanization of Indus Civilization in northwest India

Yama Dixit
David A. Hodell
Cameron A. Petrie
ResearchOpen Access09 Mar 2018
Scientific Reports

Volume: 8, P: 1-8
Fast and slow components of interstadial warming in the North Atlantic during the last glacial

Interstadial North Atlantic warming during the last glacial period involved the operation of both fast and slow components of the coupled atmosphere–ocean–sea-ice system, according to analyses from the Portuguese Margin and climate model simulations.

Vasiliki Margari
Luke C. Skinner
Polychronis C. Tzedakis
ResearchOpen Access13 Aug 2020
Communications Earth & Environment

Volume: 1, P: 1-9
Marked progress in AL amyloidosis survival: a 40-year longitudinal natural history study

Andrew Staron
Luke Zheng
Vaishali Sanchorawala
ResearchOpen Access04 Aug 2021
Blood Cancer Journal

Volume: 11, P: 1-10
Race/ethnicity in systemic AL amyloidosis: perspectives on disease and outcome disparities

Andrew Staron
Lawreen H. Connors
Vaishali Sanchorawala
ResearchOpen Access10 Nov 2020
Blood Cancer Journal

Volume: 10, P: 1-10
Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes

Pamela Feliciano
Xueya Zhou
Wendy K. Chung
ResearchOpen Access23 Aug 2019
npj Genomic Medicine

Volume: 4, P: 1-14
Author Correction: Intensified summer monsoon and the urbanization of Indus Civilization in northwest India

Yama Dixit
David A. Hodell
Cameron A. Petrie
Amendments and CorrectionsOpen Access03 Aug 2018
Scientific Reports

Volume: 8, P: 1-2
Consistently dated Atlantic sediment cores over the last 40 thousand years

Claire Waelbroeck
Bryan C. Lougheed
Martin Ziegler
ResearchOpen Access02 Sept 2019
Scientific Data

Volume: 6, P: 1-12

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