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Advanced filters: Author: Luna Jimenez-Castilla Clear advanced filters

  • The authors investigated the effect of therapies based on the JAK/STAT regulator SOCS1 to combat diabetes-induced oxidative stress. The SOCS1 gene and peptidomimetic administration prevents renal damage and atherosclerosis in streptozotocin-diabetic mice by reducing oxidative stress and enhancing antioxidant genes. Mechanistically, SOCS1 prevents activation/expression of NADPH oxidase via PI3K and STAT1 inhibition.

    • Laura Lopez-Sanz
    • Susana Bernal
    • Carmen Gomez-Guerrero
    Research
    Laboratory Investigation
    Volume: 98, P: 1276-1290