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Showing 1–2 of 2 results
Advanced filters: Author: Lunyi Xiong Clear advanced filters

  • Despite intensive investigation, stepwise reactions from diol to Taxol tetracyclic core skeleton remain unclear. Here, authors fill this gap by identifying two P450s and confirming the reaction order.

    • Chengshuai Yang
    • Yan Wang
    • Zhihua Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Modulating cholesterol metabolism can improve CD8+ T-cell-mediated immunity against tumours; genetic or pharmacological inhibition of the cholesterol esterification enzyme ACAT1 led to higher plasma membrane cholesterol levels, better T-cell receptor clustering and signalling, improved immunological synapse maturation, and enhanced antitumour activity in mice.

    • Wei Yang
    • Yibing Bai
    • Chenqi Xu
    Research
    Nature
    Volume: 531, P: 651-655