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Showing 1–2 of 2 results
Advanced filters: Author: Lutfi Huq Clear advanced filters
  • Here the authors show that tissue-resident memory and exhausted T cells in tumors are distinct populations that are shaped by relative presence or absence of TCR signals, suggesting that a tailored therapeutic strategy is needed to target each subset.

    • Thomas N. Burn
    • Jan Schröder
    • Laura K. Mackay
    ResearchOpen Access
    Nature Immunology
    Volume: 27, P: 98-109
  • Patients who express a hyperactive mutant of the kinase PI3K exhibit defective humoral immunity. Preite et al. show that overactive PI3K leads to defective class-switched antigen-specific responses to immunization, despite augmented germinal-center formation and reactivity to commensal microbes and self antigens.

    • Silvia Preite
    • Jennifer L. Cannons
    • Pamela L. Schwartzberg
    Research
    Nature Immunology
    Volume: 19, P: 986-1000