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Showing 1–2 of 2 results
Advanced filters: Author: Lydia Blachowicz Clear advanced filters
  • Constriction of the selectivity filter is assumed to be a hallmark of C-type inactivation in K+ channels. Using different high-resolution methods, this study shows a distinct C-type inactivation mechanism in a KcsA mutant that emulates Kv-channels.

    • Ahmed Rohaim
    • Bram J. A. Vermeulen
    • Markus Weingarth
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14
  • Tetrameric cationic channels specificity is determined by the sequence and structural conformation of their selectivity filter. Here, the authors show that a cationic channel from Tsukamurella paurometabola is non-selective due to a Ca2+-binding motif within its unusual proline-rich filter.

    • Balasundaresan Dhakshnamoorthy
    • Ahmed Rohaim
    • Benoît Roux
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11