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Showing 1–20 of 20 results
Advanced filters: Author: Lydia W. S. Finley Clear advanced filters
  • In 1923, Otto Warburg published his landmark study, in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His work laid the foundation for an understanding of how metabolic reconfiguration contributes to cancer onset and progression. Several researchers in the field share their thoughts on what this discovery means to them and how it has inspired their scientific journey.

    • Craig B. Thompson
    • Karen H. Vousden
    • Caroline R. Bartman
    Reviews
    Nature Metabolism
    Volume: 5, P: 1840-1843
  • Finley et al. show that Brd4 is dispensable for self-renewal and pluripotency in murine embryonic stem cells (ESCs). In metastable ESCs, Brd4 independence can be achieved by increasing the expression of the pluripotency transcription factors Oct4, Sox2 and Nanog as long as Tet1/2 are present.

    • Lydia W. S. Finley
    • Santosha A. Vardhana
    • Craig B. Thompson
    Research
    Nature Cell Biology
    Volume: 20, P: 565-574
  • Metabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment and offering insights for targeted regenerative therapies.

    • Almudena Chaves-Perez
    • Scott E. Millman
    • Scott W. Lowe
    ResearchOpen Access
    Nature
    Volume: 643, P: 468-477
  • Todorova et al. characterize the strategies through which embryos secure amino acid supply during the early phases of development. Their findings show that, in the preimplantation phase, embryos uptake whole proteins through macropinocytosis and, over time, they shift towards soluble amino acid uptake. This strategy may contribute to protecting embryos from nutrient fluctuations.

    • Pavlina K. Todorova
    • Benjamin T. Jackson
    • Lydia W. S. Finley
    Research
    Nature Metabolism
    Volume: 6, P: 127-140
  • Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

    • Benjamin T. Jackson
    • Angela M. Montero
    • Lydia W. S. Finley
    Research
    Nature Metabolism
    Volume: 7, P: 1168-1182
  • Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

    • Gizem Guzelsoy
    • Setiembre D. Elorza
    • Carlos Carmona-Fontaine
    ResearchOpen Access
    Nature
    Volume: 640, P: 534-542
  • The migration and growth of cancer cells at sites far from the initial tumour is usually fatal. Metabolic heterogeneity — variable expression of an enzyme in the initial tumour — is identified as an early step in this deadly process.

    • Sanjeethan C. Baksh
    • Lydia W. S. Finley
    News & Views
    Nature
    Volume: 605, P: 627-628
  • The adenine riboswitch was evolved into a fluorogenic aptamer by randomizing the sequence and size of the ligand-binding pocket. The resulting fluorogenic aptamer, Squash, is highly folded and was adapted for ratiometric live imaging of SAM.

    • Sourav Kumar Dey
    • Grigory S. Filonov
    • Samie R. Jaffrey
    Research
    Nature Chemical Biology
    Volume: 18, P: 180-190
  • Metastasis, the migration of tumour cells from their primary site, is associated with poor prognosis. A molecule made during cell metabolism limits metastasis, revealing that this metabolite restrains cancer progression.

    • Lydia W. S. Finley
    News & Views
    Nature
    Volume: 571, P: 39-40
  • If deprived of exogenous glutamine, naive mouse embryonic stem cells are shown to be capable of generating the amino acid from other sources to enable their proliferation; the stem cells use glutamine and glucose catabolism to maintain a high level of intracellular α-ketoglutarate and promote demethylation of chromatin and ensure sufficient expression of pluripotency-associated genes.

    • Bryce W. Carey
    • Lydia W. S. Finley
    • Craig B. Thompson
    Research
    Nature
    Volume: 518, P: 413-416
  • Restoring the function of p53 in a mouse model of pancreatic ductal adenocarcinoma leads to the accumulation of α-ketoglutarate, which increases levels of the 5-hydroxymethylcytosine chromatin modification and results in reduced tumour-cell fitness.

    • John P. Morris IV
    • Jossie J. Yashinskie
    • Scott W. Lowe
    Research
    Nature
    Volume: 573, P: 595-599
  • Like stem cells, cancer cells can rapidly proliferate but, unlike stem cells, they are mostly locked into a malignant identity. Here, Finley and Intlekofer highlight commonalities in anabolic pathways that support proliferation in cancer and stem cells, and point out unique metabolic features that influence self-renewal and differentiation.

    • Andrew M. Intlekofer
    • Lydia W. S. Finley
    Reviews
    Nature Metabolism
    Volume: 1, P: 177-188
  • Glutamine is a major fuel for proliferating cells. Here the authors show that reduced dependence on exogenous glutamine is a generalizable feature of self-renewing pluripotent stem cells that can be exploited to select for mouse and human pluripotent stem cells with high self-renewal potential.

    • Santosha A. Vardhana
    • Paige K. Arnold
    • Lydia W. S. Finley
    Research
    Nature Metabolism
    Volume: 1, P: 676-687
  • This Review presents evidence that points to a critical role for metabolic pathways in influencing processes that support the early stages of tumour development, provides examples of the role of metabolic networks intrinsic to cancer cells in tumour progression and outlines how environmental factors can affect tumour incidence.

    • Julia S. Brunner
    • Lydia W. S. Finley
    Reviews
    Nature Reviews Endocrinology
    Volume: 19, P: 134-150