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Showing 1–2 of 2 results
Advanced filters: Author: Lydie Couturier Clear advanced filters

  • The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notum patterning.

    • Lydie Couturier
    • Khalil Mazouni
    • François Schweisguth
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Asymmetric Notch signalling is important in many developmental contexts, including the division of fly sensory organ precursor (SOP) cells. Here, Notch is inactivated by Numb in the resulting pIIb daughter cell while remaining active in pIIa to direct cell fate. Using live imaging, Schweisguth and colleagues reveal that Numb and Sanpodo act together, modulating Notch trafficking to deplete it on the pIIb side of the SOP cytokinetic furrow.

    • Lydie Couturier
    • Nicolas Vodovar
    • François Schweisguth
    Research
    Nature Cell Biology
    Volume: 14, P: 131-139