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Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

B. Jack Longley
Lynda Tyrrell
Irvin Modlin
Research01 Mar 1996
Nature Genetics

Volume: 12, P: 312-314
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.

Anne E. Justice
Thomas W. Winkler
L Adrienne Cupples
ResearchOpen Access26 Apr 2017
Nature Communications

Volume: 8, P: 1-19
Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na_v1.7 mutant channel

Mutations of the Na_V1.7 voltage-gated sodium channel are implicated in abnormal pain signal transduction. Yang and colleagues perform structural modeling, mutant cycle analysis and electrophysiology on specific mutants and find that they can accurately predict their response profiles to channel blockers.

Yang Yang
Sulayman D. Dib-Hajj
Stephen G. Waxman
Research13 Nov 2012
Nature Communications

Volume: 3, P: 1-12
Transfection of rat or mouse neurons by biolistics or electroporation

Sulayman D Dib-Hajj
Jin Sung Choi
Stephen G Waxman
Protocols09 Jul 2009
Nature Protocols

Volume: 4, P: 1118-1127

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Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm

Genetic insights into biological mechanisms governing human ovarian ageing

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel

Transfection of rat or mouse neurons by biolistics or electroporation

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Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na_v1.7 mutant channel