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Showing 1–2 of 2 results
Advanced filters: Author: Lynet Nyoni Clear advanced filters

  • The ATR inhibitor ceralasertib has shown clinical activity in combination with immune-checkpoint inhibitors in several cancer types. Here the authors report the anti-tumor activity and the immunomodulatory changes, dependent on up-regulation of type I interferon pathway, following intermittent ATR inhibition in preclinical cancer models.

    • Elizabeth L. Hardaker
    • Emilio Sanseviero
    • Simon T. Barry
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal of it is important for the binding specificity of both the centriolar satellite protein PCM1 and the ULK1 complex to GABARAP subfamily proteins.

    • Martina Wirth
    • Wenxin Zhang
    • Stéphane Mouilleron
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18