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Showing 1–2 of 2 results
Advanced filters: Author: Lynn Bonetti Clear advanced filters

  • Follicular and marginal zone B (FoB and MZB, respectively) cells have divergent metabolic characteristics. Here the authors show that deficiency of glutamate cysteine ligase (Gclc), the enzyme for glutathione synthesis, differentially impacts FoB and MZB homeostasis, while specifically impeding FoB activation and downstream antiviral immunity.

    • Davide G. Franchina
    • Henry Kurniawan
    • Dirk Brenner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways involved, and show that DMF suppresses Tc17 pathogenicity in a mouse model of MS.

    • Christina Lückel
    • Felix Picard
    • Magdalena Huber
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15